NTP report on the toxicology studies of dichloroacetic acid (CAS NO. 79-43-6) in genetically modified (FVB tg.AC hemizygous) mice (Dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53tm1Brd (N5) haploinsufficient] mice (Drinking water studies)
BACKGROUND: Dichloroacetic acid is a by-product of water disinfection. We tested if dichloroacetic acid could cause cancer in two different strains of genetically modified mice. METHODS: We applied solutions containing dichloroacetic acid to the backs of male and female Tg.AC mice for 6 or 9 months...
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| Format: | eBook |
| Language: | English |
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Research Triangle Park, NC
National Toxicology Program
2007, April 2007
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| Series: | NTP GMM
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| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | BACKGROUND: Dichloroacetic acid is a by-product of water disinfection. We tested if dichloroacetic acid could cause cancer in two different strains of genetically modified mice. METHODS: We applied solutions containing dichloroacetic acid to the backs of male and female Tg.AC mice for 6 or 9 months and gave dichloroacetic acid dissolved in drinking water to male and female Tg.AC hemizygous mice and to male and female p53 haploinsufficient mice for 6 or 10 months. Animals given plain water served as the control groups. Tissues from 18 sites were examined for every animal. RESULTS: Male and female Tg.AC mice with dichloroacetic acid applied to their backs had greatly increased rates of epidermal hyperkeratosis at the site where the chemical was applied, and Tg.AC mice receiving the highest concentrations (0.5 grams per kilogram of body weight each day) developed squamous cell papillomas. In Tg.AC mice receiving dichloroacetic acid in the drinking water, a few alveolar/bronchiolar tumors of the lung were seen in exposed animals in each of the four studies. There were no increases in cancers in the p53 haploinsufficient mice given dichloroacetic acid in the drinking water. CONCLUSIONS: We conclude that dichloroacetic acid did not cause cancer in the genetically modified p53 haploinsufficient mice and gave only weakly positive responses when given to Tg.AC mice. Dichloroacetic acid did cause cancer in several other long-term studies with different rodents, and thus we conclude these genetically modified mice may not be as sensitive for detecting certain cancer-causing compounds |
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| Physical Description: | 1 PDF file (168 pages) illustrations |