NTP report on the toxicology studies of sodium bromate (CASRN 7789-38-0) in genetically modified (FVB tg.AC hemizygous) mice (Dermal and drinking water studies) and carcinogenicity studies of sodium bromate in genetically modified [B6.129-Trp53tm1Brd (N5) haploinsufficient] mice (Drinking water studies)
BACKGROUND: Sodium bromate is a by-product of water disinfection. We tested if sodium bromate could cause cancer in two different strains of genetically modified mice. METHODS: We applied solutions containing sodium bromate to the backs of male and female Tg.AC mice for 6 or 9 months, and gave sodiu...
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| Format: | eBook |
| Language: | English |
| Published: |
Research Triangle Park, NC
National Toxicology Program
March 2007, 2007
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| Series: | NTP GMM
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| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | BACKGROUND: Sodium bromate is a by-product of water disinfection. We tested if sodium bromate could cause cancer in two different strains of genetically modified mice. METHODS: We applied solutions containing sodium bromate to the backs of male and female Tg.AC mice for 6 or 9 months, and gave sodium bromate dissolved in drinking water to male and female Tg.AC and p53 mice for 6 or 10 months. The ethanol/water vehicle without any chemical was applied to the backs of control mice in the dermal studies, and animals given plain water served as the control groups for the drinking water studies. Tissues from 15 sites were examined for every animal. RESULTS: Exposure to sodium bromate either through the skin or by drinking water decreased body weights in groups given the highest concentrations. No increases in tumors were seen in males or females from either strain of mice. CONCLUSIONS: We conclude that sodium bromate did not cause cancer in the genetically modified mice used in these studies. This chemical did cause cancer in other studies with different rodents, and thus these genetically modified mice may not be as sensitive for detecting certain cancer-causing compounds |
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| Physical Description: | 1 PDF file (170 pages) illustrations |