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140122 ||| eng |
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|a 9783642596728
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| 100 |
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|a Wagner, H.
|e [editor]
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| 245 |
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|a Immunobiology of Bacterial CpG-DNA
|h Elektronische Ressource
|c edited by H. Wagner
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| 250 |
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|a 1st ed. 2000
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 2000, 2000
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| 300 |
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|a IX, 246 p
|b online resource
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|a List of Contents -- Mechanism of Action of CpG DNA -- Oligodeoxyribonucleotides with 5’-ACGT-3’ or 5’-TCGA-3’ Sequence Induce Production of Interferons -- Macrophage Activation by Immunostimulatory DNA -- Consequences of Bacterial CpG DNA-Driven Activation of Antigen-Presenting Cells -- Signal Transduction Pathways Activated by CpG-DNA -- CpG DNA Co-Stimulates Antigen-Reactive T Cells -- Role of Type I Interferons in T Cell Activation Induced by CpG DNA -- Hematopoietic Remodeling Triggered by CpG DNA -- CpG DNA Augments the Immunogenicity of Plasmid DNA Vaccines -- The Role of Bacterial DNA in Autoantibody Induction -- CpG DNA in Cancer Immunotherapy -- Use of CpG DNA for Enhancing Specific Immune Responses -- Immunostimulatory-Sequence DNA is an Effective Mucosal Adjuvant -- CpG DNA Switches on Th1 Immunity and Modulates Antigen-Presenting Cell Function -- Effects of CpG DNA on Th1/Th2 Balance in Asthma -- Responses of Human B Cells to DNA and Phosphorothioate Oligodeoxynucleotides
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| 653 |
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|a Microbiology
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| 653 |
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|a Immunology
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| 653 |
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|a Cancer
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| 653 |
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|a Cancer Biology
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| 041 |
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
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|a Current Topics in Microbiology and Immunology
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| 028 |
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|a 10.1007/978-3-642-59672-8
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| 856 |
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|u https://doi.org/10.1007/978-3-642-59672-8?nosfx=y
|x Verlag
|3 Volltext
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|a 616,079
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|a 571.96
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| 520 |
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|a Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field
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