Immunobiology of Bacterial CpG-DNA
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules...
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| Format: | eBook |
| Language: | English |
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Berlin, Heidelberg
Springer Berlin Heidelberg
2000, 2000
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| Edition: | 1st ed. 2000 |
| Series: | Current Topics in Microbiology and Immunology
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| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
| Summary: | Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field |
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| Physical Description: | IX, 246 p online resource |
| ISBN: | 9783642596728 |