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Modulating gene expression to treat diseases

Bibliographic Details
Main Author: Matharu, Navneet
Format: eBook
Language:English
Published: London Henry Stewart Talks 2021, 2021
Series:The biomedical & life sciences collection
Subjects:
Loss Of Function Mutation
Clustered Regularly Interspaced Short Palindromic Repeats
Haploinsufficiency
Crispr-cas Systems
Obesity / Genetics
Genetic Diseases, Inborn / Therapy
Gene Targeting
Molecular Genetics
Gene Therapy
Medical Genetics
Obesity / Therapy
Up-regulation
Crispr (genetics)
Gene Expression Regulation
Gene Targeting / Methods
Basic Helix-loop-helix Transcription Factors
Receptor, Melanocortin, Type 4
Gene Expression
Repressor Proteins
Online Access:
Collection: Henry Stewart Talks - Collection details see MPG.ReNa
Table of Contents:
  • Contents: Programmable DNA targeting modules
  • Effector domain functions and possibilities
  • Haploinsufficiency and its role in disease
  • CRISPRa targeting strategy to rescue Sim1 obesity
  • CRISPRa targeting strategy to treat Mc4r haploinsufficiency

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