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008 220131 ||| eng
100 1 |a Matharu, Navneet 
245 0 0 |a Modulating gene expression to treat diseases  |h Elektronische Ressource  |c Navneet Matharu 
260 |a London  |b Henry Stewart Talks  |c 2021, 2021 
300 |a 1 streaming video file (20 min.)  |b color, sound 
505 0 |a Contents: Programmable DNA targeting modules -- Effector domain functions and possibilities -- Haploinsufficiency and its role in disease -- CRISPRa targeting strategy to rescue Sim1 obesity -- CRISPRa targeting strategy to treat Mc4r haploinsufficiency 
653 |a Loss of Function Mutation 
653 |a Clustered Regularly Interspaced Short Palindromic Repeats 
653 |a Haploinsufficiency 
653 |a CRISPR-Cas Systems 
653 |a Obesity / genetics 
653 |a Genetic Diseases, Inborn / therapy 
653 |a Gene targeting 
653 |a Molecular genetics 
653 |a Gene therapy 
653 |a Medical genetics 
653 |a Obesity / therapy 
653 |a Up-Regulation 
653 |a CRISPR (Genetics) 
653 |a Gene Expression Regulation 
653 |a Gene Targeting / methods 
653 |a Basic Helix-Loop-Helix Transcription Factors 
653 |a Receptor, Melanocortin, Type 4 
653 |a Gene expression 
653 |a Repressor Proteins 
041 0 7 |a eng  |2 ISO 639-2 
989 |b HST  |a Henry Stewart Talks 
490 0 |a The biomedical & life sciences collection 
500 |a Animated audio-visual presentation with synchronized narration. - Title from title frames. - Mode of access: World Wide Web 
856 4 0 |u https://hstalks.com/bs/4844  |x Verlag  |z Streaming video file 
082 0 |a 570