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02042nam a2200301 u 4500 |
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EBX01000000000000001164967 |
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210907 r ||| eng |
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|a Chou, Roger
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|a Drug class review on cyclo-oxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs)
|h Elektronische Ressource
|b final report update 3
|c Roger Chou, Mark Helfand, Kim Peterson, Tracy Dana, Carol Roberts ; produced by Oregon Evidence-based Practice Center, Oregon Health & Science University, Mark Helfand, Director
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|a NSAIDs
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|a Portland, Oregon
|b Oregon Health & Science University
|c [2006], 2006
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| 300 |
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|a 1PDF file (43 pages)
|b illustrations
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|a Includes bibliographical references
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|a Helfand, Mark
|e [author]
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| 700 |
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|a Peterson, Kim
|e [author]
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| 700 |
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|a Dana, Tracy
|e [author]
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|a Oregon Health & Science University
|b Evidence-based Practice Center
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|a Oregon Health & Science University
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b NCBI
|a National Center for Biotechnology Information
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|a Drug class reviews
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|a Title from PDF title page. - "November 2006."
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|u https://www.ncbi.nlm.nih.gov/books/NBK10620
|3 Volltext
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|a 610
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|a Non-steroidal anti-inflammatory drugs (NSAIDs) reduce pain and inflammation by blocking cyclo-oxygenases (COX), enzymes that are needed to produce prostaglandins. Most NSAIDs block two different cyclo-oxygenases, called COX-1 and COX-2. COX-2, found in joint and muscle tissue, contributes to pain and inflammation. Many NSAIDs also block COX-1, which may contribute to development of ulcers and gastrointestinal bleeding depending on the magnitude of blockade. More recently, some NSAIDs have also been associated with an increased risk of serious cardiovascular events, such as myocardial infarction. The purpose of this review is to compare the efficacy, effectiveness, and harms of NSAIDs
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