Pharmacoeconomic review report: Naltrexone hydrochloride and bupropion hydrochloride (Contrave) (Bausch Health, Canada iInc.) :indication: an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity (e.g., controlled hypertension, type 2 diabetes mellitus, or dyslipidemia)
Naltrexone and bupropion (NB; Contrave) is a fixed-dose combination oral tablet indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults who are obese (body mass index [BMI]: ≥ 30 mg/kg2); or overweight (BMI: ≥ 27 mg/kg2) with the pres...
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| Format: | eBook |
| Language: | English |
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Ottawa (ON)
Canadian Agency for Drugs and Technologies in Health
2020, July 2020
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| Edition: | Version: Final |
| Series: | CADTH common drug review
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| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | Naltrexone and bupropion (NB; Contrave) is a fixed-dose combination oral tablet indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults who are obese (body mass index [BMI]: ≥ 30 mg/kg2); or overweight (BMI: ≥ 27 mg/kg2) with the presence of at least one weight-related comorbidity (e.g., controlled hypertension, type 2 diabetes mellitus, or dyslipidemia). It is available in one combined strength: 8 mg naltrexone hydrochloride and 90 mg bupropion hydrochloride. The recommended dosage for NB is two tablets twice daily. At the submitted price of $2.21 per tablet, the annual cost is expected to be $3,234. The sponsor's reimbursement request was as per the indication. The sponsor submitted a cost-utility analysis comparing NB taken in conjunction with standard management (SM; defined as a reduced-calorie diet and increased physical activity) to SM alone |
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| Physical Description: | 1 PDF file (29 pages) illustrations |