Chemical and Molecular Approach to Tumor Metastases

The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical...

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Bibliographic Details
Main Author: Gianni Sava ((Ed.))
Other Authors: Alberta Bergamo ((Ed.))
Format: eBook
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2018
Subjects:
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
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100 1 |a Gianni Sava  |e (Ed.) 
245 0 0 |a Chemical and Molecular Approach to Tumor Metastases  |h Elektronische Ressource 
260 |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2018 
300 |a 1 electronic resource (VIII, 256 p.) 
653 |a genomics of metastasis 
653 |a microenvironment 
653 |a metastasis niche 
653 |a Biology, life sciences / bicssc 
653 |a tumor metastasis 
653 |a chemical approaches 
653 |a molecular approaches 
653 |a clinical studies 
653 |a biology of metastasis 
653 |a metastasis druggable targets 
653 |a innovative drugs 
653 |a chemotherapy 
653 |a immunotherapy 
653 |a epigenetics of metastasis 
653 |a dynamics of metastasis 
700 1 |a Alberta Bergamo  |e (Ed.) 
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520 |a The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical agents to treat the metastatic determinants and to control of the neoplastic disease. This Special Issue on “Chemical and Molecular Approach to Tumor Metastases” will explore the impact of biology, molecular medicine and chemistry on all aspects related to tumor metastases from the biological and molecular aspects of the metastatic growth, including the relationships between the metastatic cells and the host environment, and the search for druggable determinants useful for the chemical analysis of agents selectively active against tumor metastases.  
520 |a Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies. The lack of success of chemo- and immune-therapy approaches depends on many factors among which, the inadequate capacity of the anti-tumor drugs of reaching appropriate concentrations in the organs and tissues involved in the metastatic growth is a major concern. Another factor is the complexity of the metastasis biology and of their molecular behavior, evidencing a population of tumor cells with a genetic compartment different from that of the tumor of origin.  
520 |a With the combination of invited reviews and original papers from prominent scientists working on all aspects of molecular medicine and cancer therapy, such as, but not limited to: drug delivery, genomics, chemoprevention, drug discovery, we aim to sample recent progress in molecular and chemical aspects of therapy of malignant tumors. Clinical success studies and evidences of novel compounds are particularly welcome.