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The Tumor Microenvironment of High Grade Serous Ovarian Cancer

The Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distin...

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Bibliographic Details
Main Author: Kenneth P. Nephew ((Ed.))
Other Authors: Joanna E. Burdette ((Ed.)), Anirban K. Mitra ((Ed.)), M. Sharon Stack ((Ed.))
Format: eBook
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
Subjects:
Fibroblasts
Immune Cells
Biology, Life Sciences / Bicssc
Immunotherapies
Transcriptomic
Tumor Microenvironment
Metastasis
Ovarian Cancer
Chemoresistance
Epigenetics
Genomic
Stroma
Cancer Stem Cells
Recurrence
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
Description
Summary:The Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distinct components in particular, and the role of the TME in the context of disease recurrence and development of chemoresistance. The Special Issue incorporates the current understanding of the different parts of thd TME components, including the cancer cells themselves, the cells surrounding the cancer cells or stromal cells, and the cells of the immune system, which are attracted to the site of metastases. In addition to these cells of the TME, the role of various cellular factors made by the cells of the TME are also the subject of the reviews. In addition, reviews in this Special Issue cover the complex relationships between the molecular mechanisms of HGSOC progression, including genomic, epigenomic and transcriptomic changes and changes in the immune cell landscape, as these may provide attractive new molecular targets for HGSOC therapy.
Item Description:Creative Commons (cc), https://creativecommons.org/licenses/by-nc-nd/4.0/
Physical Description:1 electronic resource (434 p.)
ISBN:books978-3-03897-555-7
9783038975557
9783038975540

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