CNS drug design
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2008, 2008
|
| Series: | Small molecule drug discovery
|
| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- Central nervous system diseases
- Drug market for CNS disorders
- Traditional CNS drug targets
- Novel CNS drug targets
- Multiple obstacles for drug delivery to CNS
- Pathways for drug exchange within the CNS
- The structure of brain capillaries impedes uptake
- Measures of drug uptake and distribution in brain
- BBB permeability and solute lipid solubility
- Tissues capillary PS and 95% equilibration time
- Cerebral blood flow affects drug uptake and Kin
- Initial uptake vs. steady-state distribution
- Plasma protein binding and brain drug uptake
- Brain capillary drug transporters
- Transporters and drug distribution across BBB
- "Enzymatic" blood-brain barrier
- Relation between bound and free drug
- Free drug distribution ratio at steady state
- BBB changes in pathology and disease
- Drug-like properties to cross the BBB
- Early findings in BBB drug uptake
- Measures of lipophilicity
- Passive permeability across lipid membranes
- Drug ionizatio