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02608nmm a2200301 u 4500 |
| 001 |
EB001083182 |
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EBX01000000000000000842589 |
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00000000000000.0 |
| 007 |
cr||||||||||||||||||||| |
| 008 |
151019 ||| eng |
| 100 |
1 |
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|a Smith, Quentin R.
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| 245 |
0 |
0 |
|a CNS drug design
|h Elektronische Ressource
|c Quentin R. Smith
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| 260 |
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|a London
|b Henry Stewart Talks
|c 2008, 2008
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| 300 |
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|a 1 online resource (1 streaming video file (46 min.)
|b color, sound)
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| 505 |
0 |
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|a Central nervous system diseases -- Drug market for CNS disorders -- Traditional CNS drug targets -- Novel CNS drug targets -- Multiple obstacles for drug delivery to CNS -- Pathways for drug exchange within the CNS -- The structure of brain capillaries impedes uptake -- Measures of drug uptake and distribution in brain -- BBB permeability and solute lipid solubility -- Tissues capillary PS and 95% equilibration time -- Cerebral blood flow affects drug uptake and Kin -- Initial uptake vs. steady-state distribution -- Plasma protein binding and brain drug uptake -- Brain capillary drug transporters -- Transporters and drug distribution across BBB -- "Enzymatic" blood-brain barrier -- Relation between bound and free drug -- Free drug distribution ratio at steady state -- BBB changes in pathology and disease -- Drug-like properties to cross the BBB -- Early findings in BBB drug uptake -- Measures of lipophilicity -- Passive permeability across lipid membranes -- Drug ionizatio
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| 653 |
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|a Central Nervous System Diseases / drug therapy
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| 653 |
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|a Drug Design
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| 653 |
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|a Brain
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| 653 |
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|a Blood-Brain Barrier
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| 653 |
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|a Molecular Targeted Therapy
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b HST
|a Henry Stewart Talks
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| 490 |
0 |
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|a Small molecule drug discovery
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| 500 |
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|a Animated audio-visual presentation with synchronized narration. - Title from title frames. - Mode of access: World Wide Web. - System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
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| 856 |
4 |
2 |
|u https://hstalks.com/bs/p/277
|3 Series (Blood-brain barrier)
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| 856 |
4 |
0 |
|u https://hstalks.com/bs/762
|x Verlag
|z Streaming video file
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| 856 |
4 |
2 |
|u https://hstalks.com/bs/p/739
|3 Series (Small molecule drug discovery)
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| 082 |
0 |
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|a 570
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