Antibody engineering of Fc effector functions
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2007, 2007
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| Series: | Monoclonal antibodies as therapeutic agents : fundamentals, therapeutic applications and latest advances
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- IgG structure and modes of action
- Human IgG Fc receptors
- Structural interactions
- Engineering strategy
- Selection of subclasses and effector functions
- Manipulation of functions
- Case study: FMAIT
- Design and engineering of inhibitory Fc mutants
- Functional properties
- Complement mediated lysis
- FcR binding
- Monocyte activation
- ADCC
- Clinical volunteer study
- Activatory mutations
- Enhanced binding to FcR
- Increased ADCC
- Possible applications