Herpes simplex virus and varicella-zoster virus Helicase-Primase inhibitors
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2011, 2011
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| Series: | Antivirals : latest developments and future progress
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- Herpesvirus infections in man
- Diseases caused by alphaherpesvirus, HSV and VZV
- Immunocompromised hosts
- Infection, latency and reactivation
- Morphology of herpesvirus virion
- Productive replication cycle
- The herpesvirus genome
- HSV and VZV antiviral therapy
- Nucleoside analogue therapy
- Historical prospective
- Genes coding for proteins targeted by antivirals
- Inhibitors of DNA synthesis
- A new target
- HSV helicase-primase complex
- Clinical potential of Helicase primase inhibitors (HPIs)
- Studying HPI in vivo
- Antiviral efficacy
- Dose response
- The effects of HPI on HSV latency
- The development of HPI antiviral drug resistance
- HPI resistant mutants growth and pathogenicity