MPG.eBooks - Table of Contents: Targeting Aß oligomers

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Bibliographic Details
Main Author:	Klein, William L.
Format:	eBook
Language:	English
Published:	London Henry Stewart Talks 2014, 2014
Series:	Drug discovery and development in the neurosciences
Subjects:	Alzheimer's Disease / Chemotherapy Neurons / Pathology Alzheimer's Disease / Diagnosis Alzheimer Disease / Pathology Neurons / Metabolism Alzheimer Disease / Etiology Amyloid Beta-peptides / Metabolism Alzheimer's Disease / Pathogenesis Brain / Metabolism Alzheimer Disease / Metabolism Alzheimer Disease / Drug Therapy Nervous System / Degeneration Amyloid Beta-protein Neurodegenerative Diseases / Metabolism
Online Access:	https://hstalks.com/bs/2729 https://hstalks.com/bs/p/684
Collection:	Henry Stewart Talks - Collection details see MPG.ReNa

Table of Contents:

The oligomer cascade hypothesis for Alzheimer's Disease
Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis
The role of AβOs in memory failure and the major facets of AD neuropathology
Mechanisms by which AβOs instigate neurotoxicity
Why AβOs accumulate in the first place
How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics
Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases