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| 008 |
151019 ||| eng |
| 100 |
1 |
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|a Klein, William L.
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| 245 |
0 |
0 |
|a Targeting Aß oligomers
|h Elektronische Ressource
|b a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease
|c William L. Klein
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| 246 |
3 |
1 |
|a pathogenic ligands that attack dendritic spines
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| 246 |
3 |
1 |
|a Targeting amyloid beta oligomers
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| 246 |
3 |
1 |
|a Targeting AB oligomers
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| 246 |
3 |
1 |
|a pathogenic ligands that attack dendritic spines
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| 260 |
|
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|a London
|b Henry Stewart Talks
|c 2014, 2014
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| 300 |
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|a 1 online resource (1 streaming video file (68 min.)
|b color, sound)
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| 505 |
0 |
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|a The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases
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| 653 |
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|a Alzheimer's disease / Chemotherapy
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| 653 |
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|a Neurons / pathology
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| 653 |
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|a Alzheimer's disease / Diagnosis
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| 653 |
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|a Alzheimer Disease / pathology
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| 653 |
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|a Neurons / metabolism
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| 653 |
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|a Alzheimer Disease / etiology
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| 653 |
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|a Amyloid beta-Peptides / metabolism
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| 653 |
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|a Alzheimer's disease / Pathogenesis
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| 653 |
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|a Brain / metabolism
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| 653 |
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|a Alzheimer Disease / metabolism
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| 653 |
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|a Alzheimer Disease / drug therapy
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| 653 |
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|a Nervous system / Degeneration
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| 653 |
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|a Amyloid beta-protein
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| 653 |
|
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|a Neurodegenerative Diseases / metabolism
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
|
| 989 |
|
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|b HST
|a Henry Stewart Talks
|
| 490 |
0 |
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|a Drug discovery and development in the neurosciences
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| 500 |
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|a Animated audio-visual presentation with synchronized narration. - Title from title frames. - Mode of access: World Wide Web. - System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
|
| 856 |
4 |
0 |
|u https://hstalks.com/bs/2729
|x Verlag
|z Streaming video file
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| 856 |
4 |
2 |
|u https://hstalks.com/bs/p/684
|3 Series
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| 082 |
0 |
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|a 570
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