Intrinsically Disordered Proteins

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on...

Full description

Main Author: Uversky, Vladimir N.
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2014, 2014
Edition:1st ed. 2014
Series:Protein Folding and Structure
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Reinventing the wheel
  • Structural heterogeneity of IDPs: When almost everything is possible
  • Typical functions of IDPs and IDPRs
  • Binding promiscuity and multitude of the disorder-based binding modes
  • IDPs/IDPRs in human diseases
  • IDPs as potential drug targets
  • Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles