Intrinsically Disordered Proteins

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on...

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Main Author: Uversky, Vladimir N.
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2014, 2014
Edition:1st ed. 2014
Series:Protein Folding and Structure
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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245 0 0 |a Intrinsically Disordered Proteins  |h Elektronische Ressource  |c by Vladimir N. Uversky 
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300 |a XV, 61 p. 13 illus., 10 illus. in color  |b online resource 
505 0 |a Reinventing the wheel -- Structural heterogeneity of IDPs: When almost everything is possible -- Typical functions of IDPs and IDPRs -- Binding promiscuity and multitude of the disorder-based binding modes -- IDPs/IDPRs in human diseases -- IDPs as potential drug targets -- Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles 
653 |a Protein Structure 
653 |a Medicinal chemistry 
653 |a Medicinal Chemistry 
653 |a Biochemistry, general 
653 |a Biochemistry 
653 |a Proteins  
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490 0 |a Protein Folding and Structure 
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520 |a In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas