Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors
In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in...
| Other Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Dordrecht
Springer Netherlands
1996, 1996
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| Edition: | 1st ed. 1996 |
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1 Overview — mechanisms of action of anti-inflammatory drugs
- 2 The three-dimensional structure of cyclooxygenases
- 3 The dilemma of two cyclooxygenases: identifying the roles of COX-1 and COX-2 in inflammation and apoptosis
- 4 Inducible enzymes with special reference to COX-2 in the inflammatory response
- 5 NSAID mechanism of action: the role of intracellular pharmacokinetics
- 6 Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs
- 7 COX-2 expression and inhibition in human monocytes
- 8 Expression and regulation of COX-2 in synovial tissues of arthritic patients
- 9 An inhibitor of injury-induced COX-2 transcriptional activation elicits neuroprotection in a brain damage model
- 10 COX-2 expression in labour
- 11 Re-evaluation of gut toxicity of NSAIDs
- 12 NSAID: can renal side effects be avoided?
- 13 Pharmacology, safety data and therapeutics of COX-2 inhibitors