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140122 ||| eng |
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|a 9783642755996
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|a Obe, Günter
|e [editor]
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|a Advances in Mutagenesis Research 2
|h Elektronische Ressource
|c edited by Günter Obe
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| 250 |
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|a 1st ed. 1990
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 1990, 1990
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| 300 |
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|a IX, 326 p
|b online resource
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|a 2 In Vitro Transformation Systems -- 3 Cytogenetics of Cell Transformation in Vitro -- 4 Molecular Changes in the in Vitro Transformation Process -- 5 Conclusion -- References
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|a The Surveillance of Birth Defects in South America: II. The Search for Geographic Clusters: Endemics -- 1 Introduction -- 2 Focus -- 3 Rumors -- 4 Endemics -- References -- Individual Genetic Counseling or Eugenics -- 1 Introduction -- 2 Individual Genetic Counseling -- 3 Eugenics -- 4 Eugenics and Individual Genetic Counseling -- References -- The Use of Intact Mammalian Cells as Metabolic Activation Systems in Mutagenicity Tests -- 1 Shortcomings of Subcellular S-9 Mix as Activation System -- 2 Intact Mammalian Cells Competent in Metabolizing Xenobiotics -- 3 Isolated and Cultured Hepatocytes -- 4 Genotoxicity Studies with Primary Hepatocytes -- 5 Epithelial Liver Cell Lines in Genotoxicity Studies -- 6 Cell-Mediated Assays in Genotoxicity Studies: Problem of Cell-to-Cell Transfer of Reactive Metabolites -- 7 Summary and Conclusions -- References -- Cytogenetics and Molecular Genetics of Cell Transformation in Vitro by Mutagens/Carcinogens -- 1 Introduction --
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|a Evolution of DNA Sequence Contributions of Mutational Bias and Selection to the Origin of Chromosomal Compartments -- 1 Introduction -- 2 Composition-Based Selection in Genomes -- 3 Effects of Mutational Bias on Genome Composition and Structure -- 4 Molecular Mechanisms of the Mutational Bias -- 5 Conclusions -- References -- Dynamic Banding for High-Resolution Analysis of Chromosomes and Assignment of DNA Replication Times -- 1 Introduction -- 2 Cell Cycle and DNA Replication -- 3 BrdUrd Incorporation and Detection -- 4 Dynamic Bands -- 5 Applications -- 6 Important Topics Concerning Dynamic Bands -- 7 Conclusion -- References -- Mutational Bias, Molecular Ecology, and Chromosome Evolution -- 1 Introduction -- 2 Sequence Organization Along the Banded Chromosome -- 3 Subclasses of Bands -- 4 Chromosome Mutations Associated with Band Subsets -- 5 The Constant Molecular Clock and Molecular Ecology -- 6 Conclusions -- References --
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|a Automated Cytogenetics in the Study of Mutagenesis and Cancer -- 1 Introduction -- 2 Image Analysis in Cytogenetics -- 3 Metaphase Location -- 4 Visual Scoring Using an Automated Microscope -- 5 Automatic Scoring of Aberrations -- 6 Cancer Cytogenetics -- 7 Conclusions -- References -- Chromosome Aberrations of Blood Lymphocytes Induced by Low-Level Doses of Ionizing Radiation -- 1 Introduction -- 2 Theoretical Considerations on the Effect of Ionizing Radiation -- 3 In Vivo Investigations on Chromosome Aberrations -- 4 In Vitro Experiments -- 5 Discussion -- 6 Conclusions -- References -- The Surveillance of Birth Defects in South America: I. The Search for Time Clusters: Epidemics -- 1 Introduction -- 2 The ECLAMC -- 3 Identifying the Population at Risk -- 4 The Monitoring of Teratogens -- 5 The Monitoring of Mutagens (Sentinel Anomalies) -- 6 What to do with the Alarms -- References --
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|a Cell Biology
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|a Environmental chemistry
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| 653 |
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|a Zoology
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| 653 |
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|a Cytology
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| 653 |
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|a Environmental Chemistry
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|a Cancer
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| 653 |
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|a Ecology
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| 653 |
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|a Anthropology
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| 653 |
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|a Ecology
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| 653 |
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|a Cancer Biology
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| 041 |
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|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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|a Advances in Mutagenesis Research
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|a 10.1007/978-3-642-75599-6
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| 856 |
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|u https://doi.org/10.1007/978-3-642-75599-6?nosfx=y
|x Verlag
|3 Volltext
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|a 590
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|a The new field of applied genetic research, genetic toxicology and mutation research investigates the muta- genicity and cancerogenicity of chemicals and other agents. Permanent changes in genes and chromosomes, or genome mutations, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Mutagenesis research has two aims: (1) to understand the molecular mechanisms leading to mutations, and (2) to prevent a thoughtless introduction of mutagenic agents into our environment. Both aspects, namely, basic and applied, will be treated in the new series Advances in Mutagenesis Research
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