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Advances in Mutagenesis Research 2

The new field of applied genetic research, genetic toxicology and mutation research investigates the muta- genicity and cancerogenicity of chemicals and other agents. Permanent changes in genes and chromosomes, or genome mutations, can be induced by a plethora of agents, including ionizing and nonio...

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Bibliographic Details
Other Authors: Obe, Günter (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 1990, 1990
Edition:1st ed. 1990
Series:Advances in Mutagenesis Research
Subjects:
Cell Biology
Environmental Chemistry
Zoology
Cytology
Cancer
Ecology 
Anthropology
Ecology
Cancer Biology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 2 In Vitro Transformation Systems
  • 3 Cytogenetics of Cell Transformation in Vitro
  • 4 Molecular Changes in the in Vitro Transformation Process
  • 5 Conclusion
  • References
  • The Surveillance of Birth Defects in South America: II. The Search for Geographic Clusters: Endemics
  • 1 Introduction
  • 2 Focus
  • 3 Rumors
  • 4 Endemics
  • References
  • Individual Genetic Counseling or Eugenics
  • 1 Introduction
  • 2 Individual Genetic Counseling
  • 3 Eugenics
  • 4 Eugenics and Individual Genetic Counseling
  • References
  • The Use of Intact Mammalian Cells as Metabolic Activation Systems in Mutagenicity Tests
  • 1 Shortcomings of Subcellular S-9 Mix as Activation System
  • 2 Intact Mammalian Cells Competent in Metabolizing Xenobiotics
  • 3 Isolated and Cultured Hepatocytes
  • 4 Genotoxicity Studies with Primary Hepatocytes
  • 5 Epithelial Liver Cell Lines in Genotoxicity Studies
  • 6 Cell-Mediated Assays in Genotoxicity Studies: Problem of Cell-to-Cell Transfer of Reactive Metabolites
  • 7 Summary and Conclusions
  • References
  • Cytogenetics and Molecular Genetics of Cell Transformation in Vitro by Mutagens/Carcinogens
  • 1 Introduction
  • Evolution of DNA Sequence Contributions of Mutational Bias and Selection to the Origin of Chromosomal Compartments
  • 1 Introduction
  • 2 Composition-Based Selection in Genomes
  • 3 Effects of Mutational Bias on Genome Composition and Structure
  • 4 Molecular Mechanisms of the Mutational Bias
  • 5 Conclusions
  • References
  • Dynamic Banding for High-Resolution Analysis of Chromosomes and Assignment of DNA Replication Times
  • 1 Introduction
  • 2 Cell Cycle and DNA Replication
  • 3 BrdUrd Incorporation and Detection
  • 4 Dynamic Bands
  • 5 Applications
  • 6 Important Topics Concerning Dynamic Bands
  • 7 Conclusion
  • References
  • Mutational Bias, Molecular Ecology, and Chromosome Evolution
  • 1 Introduction
  • 2 Sequence Organization Along the Banded Chromosome
  • 3 Subclasses of Bands
  • 4 Chromosome Mutations Associated with Band Subsets
  • 5 The Constant Molecular Clock and Molecular Ecology
  • 6 Conclusions
  • References
  • Automated Cytogenetics in the Study of Mutagenesis and Cancer
  • 1 Introduction
  • 2 Image Analysis in Cytogenetics
  • 3 Metaphase Location
  • 4 Visual Scoring Using an Automated Microscope
  • 5 Automatic Scoring of Aberrations
  • 6 Cancer Cytogenetics
  • 7 Conclusions
  • References
  • Chromosome Aberrations of Blood Lymphocytes Induced by Low-Level Doses of Ionizing Radiation
  • 1 Introduction
  • 2 Theoretical Considerations on the Effect of Ionizing Radiation
  • 3 In Vivo Investigations on Chromosome Aberrations
  • 4 In Vitro Experiments
  • 5 Discussion
  • 6 Conclusions
  • References
  • The Surveillance of Birth Defects in South America: I. The Search for Time Clusters: Epidemics
  • 1 Introduction
  • 2 The ECLAMC
  • 3 Identifying the Population at Risk
  • 4 The Monitoring of Teratogens
  • 5 The Monitoring of Mutagens (Sentinel Anomalies)
  • 6 What to do with the Alarms
  • References

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