Mouse Liver Tumors Relevance to Human Cancer Risk Symposium of the European Society ofToxicology Held in Rome, February 2–5, 1986

Peroxisome proliferation in the liver parenchymal cells is frequently observed in rats and mice exposed to certain xenobiotic compounds. Hepatic peroxisome pro­ liferation was first noted nearly twenty years ago in the livers of rats treated with the hypolipidemic drug clofibrate (Hess et aI. , 1965...

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Bibliographic Details
Other Authors: Chambers, Philip L. (Editor), Henschler, Dietrich (Editor), Oesch, Franz (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 1987, 1987
Edition:1st ed. 1987
Series:Archives of Toxicology, Supplementa
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Glutathione S-Transferase Subunits in the Mouse and Their Catalytic Activities Towards Reactive Electrophiles
  • Species Differences in Biotransformation of and Peroxisome Proliferation due to Trichloroethylene
  • The Distribution of Carcinogen Metabolizing Enzymes in the Mouse Liver: Comparison of Parenchymal and Non-Parenchymal Cell Populations
  • Investigations on the Mechanism of Liver Tumour Induction by Peroxisome Proliferators
  • DNA Damage and Repair in Mouse Liver
  • Individual Differences in DNA Repair Capacities in Man
  • Variables Influencing DNA-Binding in Mouse Liver
  • Pharmacokinetic Factors and Their Implication in the Induction of Mouse Liver Tumors by Halogenated Hydrocarbons
  • Comparative Study on the Indirect Methylation of Liver DNA Guanine by the 1-Carbon Pool in Hepatotoxicity
  • Activation ofa Cellular Proto-Oncogene in Spontaneous Liver Tumor Tissue of B6C3F1 Mouse
  • Modifying Factors
  • The Mouse in Safety Evaluation
  • Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position
  • Biology and Functional Properties of Mouse Liver Nodules
  • Invasiveness, Metastasis, and Transplantability of Mouse Liver Nodules
  • Xenobiotic-Induced Peroxisome Proliferation: Role of Tissue Specificity and Species Differences in Response in the Evaluation of the Implications for Human Health
  • The Role of Necrosis in Hepatocellular Proliferation and Liver Tumors
  • Biological Markers Characterizing the Development of Preneoplastic and Neoplastic Lesions in Rodent Liver
  • Relationship Among the Histochemically Distinguishable Early Lesions in Multistep-Multistage Hepatocarcinogenesis
  • The Histopathology and Biochemistry of Phenobarbitone-Induced Liver Nodules in C3H Mice 95
  • Molecular Basis
  • Species Differences in Enzymes Controlling Reactive Epoxides
  • Species Differences of Glucuronidation and Sulfation in Relation to Hepatocarcinogenesis
  • Nutritional and Dietary Influences on Liver Tumorigenesis in Mice and Rats
  • Anatomy, Function and Aging in the Mouse Liver
  • Sex Hormones and Neoplasia: Liver Tumors in Rodents
  • Sex Hormones and Neoplasia: Genotoxic Effects in Short Term Assays
  • Mouse and Human Liver Tumors
  • Pathogenesis of Experimental Liver Cancer Comparison with Humans
  • Author Index