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140122 ||| eng |
| 020 |
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|a 9783642716171
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| 100 |
1 |
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|a Chambers, Philip L.
|e [editor]
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| 245 |
0 |
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|a Mouse Liver Tumors
|h Elektronische Ressource
|b Relevance to Human Cancer Risk Symposium of the European Society ofToxicology Held in Rome, February 2–5, 1986
|c edited by Philip L. Chambers, Dietrich Henschler, Franz Oesch
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| 250 |
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|a 1st ed. 1987
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 1987, 1987
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| 300 |
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|a 18 illus
|b online resource
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| 505 |
0 |
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|a Glutathione S-Transferase Subunits in the Mouse and Their Catalytic Activities Towards Reactive Electrophiles -- Species Differences in Biotransformation of and Peroxisome Proliferation due to Trichloroethylene -- The Distribution of Carcinogen Metabolizing Enzymes in the Mouse Liver: Comparison of Parenchymal and Non-Parenchymal Cell Populations -- Investigations on the Mechanism of Liver Tumour Induction by Peroxisome Proliferators -- DNA Damage and Repair in Mouse Liver -- Individual Differences in DNA Repair Capacities in Man -- Variables Influencing DNA-Binding in Mouse Liver -- Pharmacokinetic Factors and Their Implication in the Induction of Mouse Liver Tumors by Halogenated Hydrocarbons -- Comparative Study on the Indirect Methylation of Liver DNA Guanine by the 1-Carbon Pool in Hepatotoxicity -- Activation ofa Cellular Proto-Oncogene in Spontaneous Liver Tumor Tissue of B6C3F1 Mouse -- Modifying Factors --
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| 505 |
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|a The Mouse in Safety Evaluation -- Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position -- Biology and Functional Properties of Mouse Liver Nodules -- Invasiveness, Metastasis, and Transplantability of Mouse Liver Nodules -- Xenobiotic-Induced Peroxisome Proliferation: Role of Tissue Specificity and Species Differences in Response in the Evaluation of the Implications for Human Health -- The Role of Necrosis in Hepatocellular Proliferation and Liver Tumors -- Biological Markers Characterizing the Development of Preneoplastic and Neoplastic Lesions in Rodent Liver -- Relationship Among the Histochemically Distinguishable Early Lesions in Multistep-Multistage Hepatocarcinogenesis -- The Histopathology and Biochemistry of Phenobarbitone-Induced Liver Nodules in C3H Mice 95 -- Molecular Basis -- Species Differences in Enzymes Controlling Reactive Epoxides -- Species Differences of Glucuronidation and Sulfation in Relation to Hepatocarcinogenesis --
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| 505 |
0 |
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|a Nutritional and Dietary Influences on Liver Tumorigenesis in Mice and Rats -- Anatomy, Function and Aging in the Mouse Liver -- Sex Hormones and Neoplasia: Liver Tumors in Rodents -- Sex Hormones and Neoplasia: Genotoxic Effects in Short Term Assays -- Mouse and Human Liver Tumors -- Pathogenesis of Experimental Liver Cancer Comparison with Humans -- Author Index
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| 653 |
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|a Pharmacy
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| 653 |
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|a Pharmacology
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| 653 |
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|a Oncology
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| 700 |
1 |
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|a Henschler, Dietrich
|e [editor]
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| 700 |
1 |
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|a Oesch, Franz
|e [editor]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
0 |
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|a Archives of Toxicology, Supplementa
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| 028 |
5 |
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|a 10.1007/978-3-642-71617-1
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-642-71617-1?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
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|a 615
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| 520 |
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|a Peroxisome proliferation in the liver parenchymal cells is frequently observed in rats and mice exposed to certain xenobiotic compounds. Hepatic peroxisome pro liferation was first noted nearly twenty years ago in the livers of rats treated with the hypolipidemic drug clofibrate (Hess et aI. , 1965; Svoboda and Azarnoff, 1966). Subsequently, several structurally unrelated hypolipidemic compounds were found to induce marked hepatomegaly and hepatic peroxisome proliferation in rats and mice, which led to the suggestion of a possible relationship between peroxisome proliferation and lipid metabolism (Reddy and Krishnakantha, 1975) as well as to the identification of a peroxisomal fatty acid f3-oxidation enzyme sys tem in the rat liver (Lazarow and DeDuve 1976). A second major class of per ox i some proliferators was identified nearly ten years ago, with the discovery that the dietary administration of a widely used phthalate-ester plasticizer di(2-ethylhex yl)phthalate (DEHP) to rats, results in the induction of peroxisomal enzymes in liver (Reddy et aL 1976a). Hypolipidemic drugs and phthalate-ester plasticizers constitute two major and important categories of chemicals with profound peroxisome proliferative property (Reddy et aL 1982; Reddy and Lalwani 1983). These two classes of xenobiotics now have important roles. First, the hypolipi demic drugs are increasingly used in the control of hyperlipidemia, a major risk factor for developing coronary heart disease
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