Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer US
2002, 2002
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| Edition: | 1st ed. 2002 |
| Series: | Advances in Experimental Medicine and Biology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- Dissociation of the Functional Contribution of Graft-Derived Axons and Dendrites in Rotational Asymmetry
- Enhancement of Motor Performance after Bilateral Transplantation
- References
- 7. Directions for Future Research
- Analysis of Early Events in Graft-Host Interactions
- Trophic Considerations
- Neurotransmitter Mechanisms
- Supplemental Restoration of the Interrupted Nigro-Striato-Nigral Loop by Striatal/Nigral Double Grafts
- References
- 1. Introduction
- Dopamine and Parkinson’s Disease
- Experimental Models of Parkinsonism in Laboratory Animals
- Graft-Assisted Neural Reconstruction (“Brainware Engineering”?)
- References
- 2. Biology And Pathology of the Weaver Mutant Mouse
- Cellular and Molecular Genetics of the Weaver Mutation
- Alterations of the Mesotelencephalic Dopamine Projection System
- Cerebellar Phenotype of the Weaver Mutant
- Hippocampal Morphology
- Biology of Normal ? Mutant Cell Associations
- Behavioral Phenotype
- Structural Clues to the Weaver Riddle
- References
- 3. Histochemical Properties of Intrastriatal Mesencephalic Grafts
- Methodological Considerations
- Expression of Catecholaminergic Neurotransmitter-Related Molecules and Quantitative Aspects of Dopaminergic Neuron Survival
- Comparative Survival of Dopaminergic Neurons in Grafts Placed in Weaver and in 6-OHDA Lesion Hosts
- Expression of Neuropeptides and Structural Proteins
- References
- 4. Structural Correlates of Process Outgrowth and Circuit Reconstruction
- Axonal Reinnervation of the Host Striatum
- Synaptic Investment of Graft-Derived Dopamine Terminals
- Compartmental Specificity of the Striatal Reinnervation
- Innervation of Nonstriatal Regions by the Grafts
- Chemoaffinity and Axon-Target Recognition in Development and in Transplantation
- Dendrite Extension from the Graft into the Host Striatum
- Expression of Molecules Related to Axonal and Dendritic Outgrowth
- References
- 5. Neurochemical Indices of Functional Restoration
- Dopamine Uptake Markers
- Autoradiography of [3H]Dopamine Uptake
- Dopamine Receptors
- Neurotensin Receptors
- Excitatory and Inhibitory Amino Acid Receptors
- References
- 6. Behavioral Recovery of Functional Responses
- Unilateral Grafts and Circling Behavior
- Correlationof Turning Bias with Structural and Biochemical Parameters