Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease

Bibliographic Details
Main Author: Triarhou, Lazaros C.
Format: eBook
Published: New York, NY Springer US 2002, 2002
Edition:1st ed. 2002
Series:Advances in Experimental Medicine and Biology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Dissociation of the Functional Contribution of Graft-Derived Axons and Dendrites in Rotational Asymmetry
  • Enhancement of Motor Performance after Bilateral Transplantation
  • References
  • 7. Directions for Future Research
  • Analysis of Early Events in Graft-Host Interactions
  • Trophic Considerations
  • Neurotransmitter Mechanisms
  • Supplemental Restoration of the Interrupted Nigro-Striato-Nigral Loop by Striatal/Nigral Double Grafts
  • References
  • 1. Introduction
  • Dopamine and Parkinson’s Disease
  • Experimental Models of Parkinsonism in Laboratory Animals
  • Graft-Assisted Neural Reconstruction (“Brainware Engineering”?)
  • References
  • 2. Biology And Pathology of the Weaver Mutant Mouse
  • Cellular and Molecular Genetics of the Weaver Mutation
  • Alterations of the Mesotelencephalic Dopamine Projection System
  • Cerebellar Phenotype of the Weaver Mutant
  • Hippocampal Morphology
  • Biology of Normal ? Mutant Cell Associations
  • Behavioral Phenotype
  • Structural Clues to the Weaver Riddle
  • References
  • 3. Histochemical Properties of Intrastriatal Mesencephalic Grafts
  • Methodological Considerations
  • Expression of Catecholaminergic Neurotransmitter-Related Molecules and Quantitative Aspects of Dopaminergic Neuron Survival
  • Comparative Survival of Dopaminergic Neurons in Grafts Placed in Weaver and in 6-OHDA Lesion Hosts
  • Expression of Neuropeptides and Structural Proteins
  • References
  • 4. Structural Correlates of Process Outgrowth and Circuit Reconstruction
  • Axonal Reinnervation of the Host Striatum
  • Synaptic Investment of Graft-Derived Dopamine Terminals
  • Compartmental Specificity of the Striatal Reinnervation
  • Innervation of Nonstriatal Regions by the Grafts
  • Chemoaffinity and Axon-Target Recognition in Development and in Transplantation
  • Dendrite Extension from the Graft into the Host Striatum
  • Expression of Molecules Related to Axonal and Dendritic Outgrowth
  • References
  • 5. Neurochemical Indices of Functional Restoration
  • Dopamine Uptake Markers
  • Autoradiography of [3H]Dopamine Uptake
  • Dopamine Receptors
  • Neurotensin Receptors
  • Excitatory and Inhibitory Amino Acid Receptors
  • References
  • 6. Behavioral Recovery of Functional Responses
  • Unilateral Grafts and Circling Behavior
  • Correlationof Turning Bias with Structural and Biochemical Parameters