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140122 ||| eng |
| 020 |
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|a 9781461506997
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| 100 |
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|a Triarhou, Lazaros C.
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| 245 |
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|a Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease
|h Elektronische Ressource
|c by Lazaros C. Triarhou
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| 250 |
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|a 1st ed. 2002
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| 260 |
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|a New York, NY
|b Springer US
|c 2002, 2002
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| 300 |
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|a X, 148 p
|b online resource
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|a Dissociation of the Functional Contribution of Graft-Derived Axons and Dendrites in Rotational Asymmetry -- Enhancement of Motor Performance after Bilateral Transplantation -- References -- 7. Directions for Future Research -- Analysis of Early Events in Graft-Host Interactions -- Trophic Considerations -- Neurotransmitter Mechanisms -- Supplemental Restoration of the Interrupted Nigro-Striato-Nigral Loop by Striatal/Nigral Double Grafts -- References
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| 505 |
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|a 1. Introduction -- Dopamine and Parkinson’s Disease -- Experimental Models of Parkinsonism in Laboratory Animals -- Graft-Assisted Neural Reconstruction (“Brainware Engineering”?) -- References -- 2. Biology And Pathology of the Weaver Mutant Mouse -- Cellular and Molecular Genetics of the Weaver Mutation -- Alterations of the Mesotelencephalic Dopamine Projection System -- Cerebellar Phenotype of the Weaver Mutant -- Hippocampal Morphology -- Biology of Normal ? Mutant Cell Associations -- Behavioral Phenotype -- Structural Clues to the Weaver Riddle -- References -- 3. Histochemical Properties of Intrastriatal Mesencephalic Grafts -- Methodological Considerations -- Expression of Catecholaminergic Neurotransmitter-Related Molecules and Quantitative Aspects of Dopaminergic Neuron Survival -- Comparative Survival of Dopaminergic Neurons in Grafts Placed in Weaver and in 6-OHDA Lesion Hosts -- Expression of Neuropeptides and Structural Proteins -- References --
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|a 4. Structural Correlates of Process Outgrowth and Circuit Reconstruction -- Axonal Reinnervation of the Host Striatum -- Synaptic Investment of Graft-Derived Dopamine Terminals -- Compartmental Specificity of the Striatal Reinnervation -- Innervation of Nonstriatal Regions by the Grafts -- Chemoaffinity and Axon-Target Recognition in Development and in Transplantation -- Dendrite Extension from the Graft into the Host Striatum -- Expression of Molecules Related to Axonal and Dendritic Outgrowth -- References -- 5. Neurochemical Indices of Functional Restoration -- Dopamine Uptake Markers -- Autoradiography of [3H]Dopamine Uptake -- Dopamine Receptors -- Neurotensin Receptors -- Excitatory and Inhibitory Amino Acid Receptors -- References -- 6. Behavioral Recovery of Functional Responses -- Unilateral Grafts and Circling Behavior -- Correlationof Turning Bias with Structural and Biochemical Parameters --
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| 653 |
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|a Neuroscience
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| 653 |
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|a Transplantation
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|a Public health
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| 653 |
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|a Neurosciences
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|a Transplantation of organs, tissues, etc
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| 653 |
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|a Public Health
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| 041 |
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
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|a Advances in Experimental Medicine and Biology
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| 028 |
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|a 10.1007/978-1-4615-0699-7
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| 856 |
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|u https://doi.org/10.1007/978-1-4615-0699-7?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
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|a 612.8
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