Principles in General Pharmacology
| Main Authors: | , , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
1988, 1988
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| Edition: | 1st ed. 1988 |
| Series: | Springer Series in Pharmacologic Science
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 8 Pharmacodynamics: The Interaction of Drugs with Receptors
- Pharmacologic Receptors
- Formation of the Drug-Receptor Complex
- Classical Theory
- Alterations in Classical Drug-Receptor Theory and Alternative Approaches
- Dissociation Constants
- Drug Combinations: Isoboles
- A Changing Receptor Concentration: Modification of Rate Equations
- References
- 9 Radioligand Binding
- Direct Binding
- Analysis of Receptor Subtypes
- Radioligand-Binding Techniques
- References
- Appendix: Mathematical Tables
- Anatomical Sites of Biotransformation
- Biotransformation Reactions
- Factors Affecting Drug Metabolism
- Biotransformations of Selected Common Drugs
- References
- 5 Introduction to Specific Drug Action and Membrane Surface Phenomena
- Nonspecific Drug Action
- Specific Drug Action: The Development of the Concept of Receptors
- Coated Pits and Coated Vesicles
- Membrane Capping
- Conclusion
- References
- 6 Drugs and Receptors: Chemical Bonding
- General Principles
- Types of Bonds
- Bond Formation in the Drug-Receptor Interaction
- References
- Appendix A. Physical Constants
- Appendix B. Comparison of Atomic, Ionic, and Hydrated Radii of Some Chemical Elements
- Appendix C. Structures of Drug Groups
- 7 The Rate of Drug-Receptor Interactions
- Measuring the Rate of Chemical Reactions
- Rates of Equilibrium Reactions
- Rate of the Drug-Receptor Interaction
- Influence of Diffusion on Reaction Rate
- Suggested Reading
- 1 General Principles: History and Overview
- Historical Perspective
- Principles
- Overview of Pharmacologic Principles
- References
- 2 Dose-Effect Relations
- Dose-Effect Graphs: Potency and Efficacy
- Antagonists
- Quantal (All-or-None) Dose-Response Relations
- Additivity and Synergism
- References
- 3 Pharmacokinetics
- Absorption
- Diffusion
- Rate Constant for Absorption
- Lipid-Water Partition Coefficient
- Transport Mechanisms
- Electrochemical Potential
- The Liver
- Drug Elimination
- Volume of Distribution
- Clearance
- Drug-Protein Binding
- Protein Binding and Disease
- Renal Excretion
- Glomerular Filtration
- Urine pH and Clearance
- Hepatic Clearance
- Intravenous Dosing
- Repeated Intravenous Injections
- Intravenous Infusion
- Absorption and Elimination
- Extravascular Multiple Dosing
- Time Course of Effect and Drug Receptor Concentration
- References
- 4 Drug Metabolism (Biotransformation)
- General Principles