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| 008 |
140122 ||| eng |
| 020 |
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|a 9781461237785
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| 100 |
1 |
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|a Tallarida, Ronald J.
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| 245 |
0 |
0 |
|a Principles in General Pharmacology
|h Elektronische Ressource
|c by Ronald J. Tallarida, Robert B. Raffa, Paul McGonigle
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| 250 |
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|a 1st ed. 1988
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| 260 |
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|a New York, NY
|b Springer New York
|c 1988, 1988
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| 300 |
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|a XIII, 243 p
|b online resource
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| 505 |
0 |
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|a 8 Pharmacodynamics: The Interaction of Drugs with Receptors -- Pharmacologic Receptors -- Formation of the Drug-Receptor Complex -- Classical Theory -- Alterations in Classical Drug-Receptor Theory and Alternative Approaches -- Dissociation Constants -- Drug Combinations: Isoboles -- A Changing Receptor Concentration: Modification of Rate Equations -- References -- 9 Radioligand Binding -- Direct Binding -- Analysis of Receptor Subtypes -- Radioligand-Binding Techniques -- References -- Appendix: Mathematical Tables
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| 505 |
0 |
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|a Anatomical Sites of Biotransformation -- Biotransformation Reactions -- Factors Affecting Drug Metabolism -- Biotransformations of Selected Common Drugs -- References -- 5 Introduction to Specific Drug Action and Membrane Surface Phenomena -- Nonspecific Drug Action -- Specific Drug Action: The Development of the Concept of Receptors -- Coated Pits and Coated Vesicles -- Membrane Capping -- Conclusion -- References -- 6 Drugs and Receptors: Chemical Bonding -- General Principles -- Types of Bonds -- Bond Formation in the Drug-Receptor Interaction -- References -- Appendix A. Physical Constants -- Appendix B. Comparison of Atomic, Ionic, and Hydrated Radii of Some Chemical Elements -- Appendix C. Structures of Drug Groups -- 7 The Rate of Drug-Receptor Interactions -- Measuring the Rate of Chemical Reactions -- Rates of Equilibrium Reactions -- Rate of the Drug-Receptor Interaction -- Influence of Diffusion on Reaction Rate -- Suggested Reading --
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| 505 |
0 |
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|a 1 General Principles: History and Overview -- Historical Perspective -- Principles -- Overview of Pharmacologic Principles -- References -- 2 Dose-Effect Relations -- Dose-Effect Graphs: Potency and Efficacy -- Antagonists -- Quantal (All-or-None) Dose-Response Relations -- Additivity and Synergism -- References -- 3 Pharmacokinetics -- Absorption -- Diffusion -- Rate Constant for Absorption -- Lipid-Water Partition Coefficient -- Transport Mechanisms -- Electrochemical Potential -- The Liver -- Drug Elimination -- Volume of Distribution -- Clearance -- Drug-Protein Binding -- Protein Binding and Disease -- Renal Excretion -- Glomerular Filtration -- Urine pH and Clearance -- Hepatic Clearance -- Intravenous Dosing -- Repeated Intravenous Injections -- Intravenous Infusion -- Absorption and Elimination -- Extravascular Multiple Dosing -- Time Course of Effect and Drug Receptor Concentration -- References -- 4 Drug Metabolism (Biotransformation) -- General Principles --
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| 653 |
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|a Pharmacy
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| 653 |
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|a Pharmacology
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| 700 |
1 |
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|a Raffa, Robert B.
|e [author]
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| 700 |
1 |
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|a McGonigle, Paul
|e [author]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
0 |
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|a Springer Series in Pharmacologic Science
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| 028 |
5 |
0 |
|a 10.1007/978-1-4612-3778-5
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-1-4612-3778-5?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 615
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