1 “...We selected studies on screening versus no screening, delayed screening, or usual care...”

2 “...We selected studies on screening versus no screening, delayed screening, or usual care...”

3 “...One large, fair-quality randomized trial nested within a population-based cohort study found...”

4 “...One large, fair-quality randomized trial nested within a population-based cohort study found...”

5 “...We included studies of screening for hypertension in asymptomatic children and studies of benefits...”

6 “...We included studies of screening for hypertension in asymptomatic children and studies of benefits...”

7 “...Observational studies were included. Studies conducted in resource-poor settings were included...”

8 “...Observational studies were included. Studies conducted in resource-poor settings were included...”

9 “... was not associated with increased risk of cardiovascular events. A large observational study also found initiation...”

10 “... was not associated with increased risk of cardiovascular events. A large observational study also found initiation...”

11 “...% CI, 0.91 to 1.20]), though statistical heterogeneity was present (I2=52%), and one trial found...”

12 “...% CI, 0.91 to 1.20]), though statistical heterogeneity was present (I2=52%), and one trial found...”

13 “...Limited evidence from head-to-head trials found that entecavir and pegylated interferon alfa-2a had...”

14 “...Limited evidence from head-to-head trials found that entecavir and pegylated interferon alfa-2a had...”

15 “...Four studies found screening questions associated with low accuracy compared to visual acuity...”

16 “...Four studies found screening questions associated with low accuracy compared to visual acuity...”

17 “...-risk populations. No study evaluated harms associated with treatment for screen-detected bladder cancer...”

18 “...-risk populations. No study evaluated harms associated with treatment for screen-detected bladder cancer...”

19 “...DATA EXTRACTION: One investigator abstracted details about each article's study design, patient...”

20 “...DATA EXTRACTION: One investigator abstracted details about each article's study design, patient...”