| Summary: | The ATSDR Interaction Profile succinctly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. Each peer-reviewed profile identifies and reviews the key literature that describes toxicologic properties of the featured mixtures. Chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene, p,p'-DDE (the predominant metabolite of p,p'-DDT), methylmercury, and polychlorinated biphenyls (PCBs) occur with high frequency in water, sediment, and fish from the North American Great Lakes and occur, to varying degrees, in other dietary components including fish from other parts of the world (e.g., the Baltic Sea), human milk, dairy products, and meat. The purposes of this profile are (1) to evaluate data (if available) on health hazards, and their dose-response relationships, from oral exposure to this five-component mixture, (2) to evaluate data on the joint toxic actions of components of this mixture, and (3) to make recommendations for exposure-based assessments of the potential impact of joint toxic action of the mixture on public health
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