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Biological Liquid-Liquid Phase Separation, Biomolecular Condensates, and Membraneless Organelles

This reprint presents recent developments in the field of biological liquid-liquid phase separation (LLPS, also known as biomolecular condensation). LLPS and related biogenesis of various membraneless organelles (MLOs) and biomolecular condensates (BMCs) represent fundamental molecular mechanisms go...

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Bibliographic Details
Main Author: Uversky, Vladimir N.
Format: eBook
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
Subjects:
Cytoophidium
Membrane-less Organelle
Actin
Chromatin Organization
N/a
Liquid-liquid Phase Separation
Paramyxoviruses
Coacervate
Negative Staining Transmission Electron Microscopy (ns-tem)
Transcription
Molecular Dynamics
Intrinsically Disordered Region
Saccharomyces Cerevisiae
Fluorescence Recovery After Photobleaching (frap)
Polyethylene Glycol (peg) Precipitation Assays
Time-lapse Afm Imaging
Lipid Bilayer
Taylor Dispersion Analysis (tda)
Nuclear Condensate
P-body
Nst1
Dna Damage Repair
Super-enhancer
Congo Red
Phase Separation
Proteins With Low Complexity
Research & Information: General / Bicssc
Biology, Life Sciences / Bicssc
Drosophila
Polyampholyte Domain
Actin-binding Proteins
Cholesterol
Phase-separated Condensates
Human Diseases
Ingression
Membraneless Organelles
Actin Polymerization
Amyloid Aggregation
Ctp Synthase
Membrane
Quantitative Imaging
Stimulated Emission Depletion (sted)
Follicle Cell
Alzheimer's Disease
Aggregation-prone Domain
Hendra Virus
Intrinsically Disordered Proteins
Signaling Proteins
Nucleolus
Nuclear Speckle
Small-angle X-ray Scattering (saxs)
Amyloid-like Fibrils
Epithelium
Liquid-liquid Phase Separation (llps)
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
Description
Summary:This reprint presents recent developments in the field of biological liquid-liquid phase separation (LLPS, also known as biomolecular condensation). LLPS and related biogenesis of various membraneless organelles (MLOs) and biomolecular condensates (BMCs) represent fundamental molecular mechanisms governing the spatio-temporal organization of the intracellular space. In fact, MLOs and BMCs, being liquid droplets, represent specific compartments within a cell that are not enclosed by a lipid membrane. Most biological LLPS processes are reversible, and many MLOs/BMCs exist transiently; they rapidly emerge when conditions are changed and rapidly disintegrate as soon as the original conditions are restored, thereby showing a characteristic "now you see me, now you don't" behavior. Numerous MLOs/BMCs are found inside eukaryotic cells, where they exist as liquid droplets (or cellular bodies, puncta, etc.) in the cytoplasm, nucleoplasm, mitochondrial matrix, and stroma of chloroplasts. Furthermore, MLOs/BMCs are commonly observed in Archaea, bacteria, and, likely, viruses. MLOs/BMCs have numerous crucial functions, and their biogenesis is known to be controlled by various external factors and environmental cues, such as changes in temperature, pH, and ionic strength of the solution. All of these have garnered the close attention of many researchers to biological LLPS, MLOs, and BMCs.
Item Description:Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/
Physical Description:1 electronic resource (202 p.)
ISBN:9783036589305
9783036589312
books978-3-0365-8930-5

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