NTP technical report on the toxicology and carcinogenesis studies of TRIM(r)\VX in wistar han [Crl:WI(Han)] rats and B6C3F1/N mice (Inhalation studies)
CONCLUSIONS: Under the conditions of these 2-year inhalation studies, there was equivocal evidence of carcinogenic activity (see Explanation of Levels of Evidence; a summary of the Peer Review Panel comments and the public discussion on this Technical Report appears in Appendix\sK) of TRIM\sVX in ma...
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| Format: | eBook |
| Language: | English |
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Research Triangle Park, North Carolina
National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services
2016, November 2016
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| Series: | NTP TR
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| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | CONCLUSIONS: Under the conditions of these 2-year inhalation studies, there was equivocal evidence of carcinogenic activity (see Explanation of Levels of Evidence; a summary of the Peer Review Panel comments and the public discussion on this Technical Report appears in Appendix\sK) of TRIM\sVX in male Wistar Han rats based on the combined occurrences of alveolar/bronchiolar adenoma or carcinoma of the lung. There was equivocal evidence of carcinogenic activity of TRIM\sVX in female Wistar Han rats based on the occurrences of alveolar/bronchiolar adenoma of the lung. There was clear evidence of carcinogenic activity of TRIM\sVX in male B6C3F1/N mice based on the increased combined incidences of alveolar/bronchiolar adenoma or carcinoma of the lung. There was clear evidence of carcinogenic activity of TRIM\sVX in female B6C3F1/N mice based on the increased combined incidences of alveolar/bronchiolar adenoma or carcinoma (primarily carcinoma) of the lung. TRIM(R)\ VX: TRIM\VX is a metalworking fluid used as a lubricant and coolant liquid and for cleaning tools and parts during cutting, drilling, milling, and grinding. The metalworking fluid class was nominated by the National Institute for Occupational Safety and Health (NIOSH) for study by the National Toxicology Program because of high production volumes, the large number of occupationally exposed workers, the lack of carcinogenicity and chronic toxicology data, and because epidemiologic data indicate an increased incidence of laryngeal cancer in workers exposed to metalworking fluids. TRIM\sVX was selected as an example soluble oil metalworking fluid following chemical analysis and collaboration with NIOSH. Male and female Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice were exposed to TRIM\sVX by inhalation for 3\smonths or 2\syears. Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichia coli, and rat and mouse peripheral blood erythrocytes. Exposure to TRIM\sVX resulted in increased incidences of nonneoplastic lesions of the lung, nose, and larynx in male and female rats and mice, the bronchial lymph node in male and female rats and male mice, and the mediastinal lymph node in male and female rats |
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| Physical Description: | 1 PDF file (various pagings) illustrations |