Familial Cardiomyopathies Methods and Protocols

This volume covers the latest advances in technologies that look at familial cardiomyopathies in greater detail, and provides new computational and experimental models that model, study, and detect disease at earlier stages. Together, this allows interdisciplinary research experiments to provide new...

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Bibliographic Details
Other Authors: Regnier, Michael (Editor), Childers, Matthew (Editor)
Format: eBook
Language:English
Published: New York, NY Humana 2024, 2024
Edition:1st ed. 2024
Series:Methods in Molecular Biology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Echocardiography to Assess Cardiac Structure and Function in Genetic Cardiomyopathies
  • MRI Quantification of Cardiac Structure and Function in Cardiomyopathy Patients
  • Atomistic Simulations of Sarcomere Proteins
  • Design Principles and Benefits of Spatially Explicit Models of Myofilament Function
  • Computational Modeling of Cardiac Electrophysiology
  • Computational Modeling and Simulation of the Fibrotic Human Atria
  • A Semi-Automatic Pipeline for Generation of Large Cohorts of Four-Chamber Heart Meshes
  • Genomic Engineering of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
  • The GENTIL Method for Isolation of Human Adult Cardiomyocytes from Cryopreserved Tissue for Proteomic Analyses
  • Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments
  • Protocols for Myosin and Actin-Myosin Assays using Rapid, Stopped-Flow Kinetics
  • Measuring the Contractile Kinetics of Isolated Myofibrils from Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte (hiPSC-CM) Models of Cardiomyopathy