| Summary: | The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. The common name, tribufos, is used throughout this Toxicological Profile for S,S,S-Tributylphosphorotrithioate (systematic name). Tribufos (Chemical Abstracts Service [CAS] Registry Number78-48-8) is a colorless to pale yellow liquid with a skunk-like odor (Tomlin 2003). Tribufos is used onlyas a defoliant (a chemical that removes leaves) for cotton plants (CalEPA 2004; Tomlin 2003). Tribufos is not for residential use or other non-occupational uses. The U.S. Geological Survey (USGS) Pesticide National Synthesis Project estimated that approximately 2 million pounds of tribufos were applied to cotton crops in 2013 (USGS 2016) and about 2.8 million pounds were applied in in 2016 (USGS 2019).Approximately 9-16 million acres of cotton are planted annually in the United States, and tribufos is one of several defoliants that may be applied to these crops (USDA 2016a). It is applied as a liquid product by aerial or ground boom spraying (EPA 2006b)
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