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Optic Neuropathies Current and Future Strategies for Optic Nerve Protection and Repair

Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of...

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Bibliographic Details
Main Author:	Tsai, Rongkung
Other Authors:	Miller, Neil R.
Format:	eBook
Language:	English
Published:	Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
Subjects:	Azithromycin Microglia Microcystic Macular Degeneration Models Atypical Optic Neuritis Treatment Tp53 Regulated Inhibitor Of Apoptosis 1 Astrocytes Visual Evoked Potential Glaucomatous Optic Neuropathy Glaucoma Epigenetics Retinal Ganglion Cells Erythropoietin Scleral Fibroblasts Neuroprotection Optic Neuropathy Oligodendrocyte Precursor Cells Leber’s Hereditary Optic Neuropathy Zebrafish Oligodendrocytes Hereditary Optic Neuropathy Retinal Ganglion Cell Death Neuronal Survival Pioglitazone Oncomodulin Mog Lhon Klf4 Myelin Tbp Associated Factor 9 Naion Sox2 Hsf1 A8 Diabetes Axonal Degeneration Ischemic Optic Neuropathy Rodents Mir-29 Dna Damage Lamina Cribrosa Optic Nerve Head Oct4 Proliferation Secondary Degeneration Retina Optic Nerve Transcriptome Typical Optic Neuritis Regeneration Inflammation Optic Nerve Protection Neuromyelitis Optica Spectrum Disease Cns Repair N/a Myeloid Cells Astrocyte Transcription Cns Injury Medicine / Bicssc Retinal Ganglion Cell Neural Injury Oligodendrocyte Idebenone Blood-brain Barrier Pattern Electroretinogram Lamina Cribrosa Cells Fibrosis Nonarteritic Anterior Ischemic Optic Neuropathy Complement Müller Cell Mitochondrial Disorder Apoptosis Neuro-ophthalmology Nmo Glial Cells Whole Exome Sequencing Optic Nerve Injury Rat Anterior Ischemic Optic Neuropathy Model Neural Ischemia Yamanaka Factors Synaptamide Neural Inflammation Extracellular Matrix Neuroimmunology Ms Prevention Oxidative Stress Aquaporin-4 Bid Mitochondrial Optic Neuropathy Intraocular Pressure Nuclear Modifier Genes Gene Expression Optic Nerve Regeneration Optic Nerve Crush Ocular Coherence Tomography Myelin Oligodendrocyte Glycoprotein
Online Access:	https://directory.doabooks.org/handle/20.500.12854... https://www.mdpi.com/books/book/7241
Collection:	Directory of Open Access Books - Collection details see MPG.ReNa

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Summary:	Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma.
Item Description:	Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/
Physical Description:	1 electronic resource (322 p.)
ISBN:	books978-3-0365-7504-9 9783036575056 9783036575049

Optic Neuropathies Current and Future Strategies for Optic Nerve Protection and Repair

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