Trials for Cerebellar Ataxias From Cellular Models to Human Therapies
Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the p...
| Other Authors: | , , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Cham
Springer International Publishing
2023, 2023
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| Edition: | 1st ed. 2023 |
| Series: | Contemporary Clinical Neuroscience
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Part I: Basic Science of Cerebellum and Ataxias
- Functional anatomy of the cerebellum
- Cerebellar physiology
- Cerebellar biochemistry/pharmacology
- Genetics of dominant ataxias
- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics
- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches
- Ion Channel Genes and Ataxia
- Part II: Biomarkers and tools of trials
- How to Design a Therapeutic Trial in SCAs
- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers
- Clinical rating scales for ataxia
- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding
- Cerebellar learning in the prism adaptation task
- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias
- Part III: Autosomal Dominant Cerebellar Ataxias
- Riluzole in progressive cerebellar ataxias
- ASOs against ATXN2 in preclinical and phase 1 trials
- Antisense oligonucleotide therapy against SCA3
- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities
- Experimental neurotransplantation for cerebellar ataxias
- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside
- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia
- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias
- Physical therapy in Cerebellar Ataxia
- Part IV: Autosomal Recessive Cerebellar Ataxias
- Recent advances on therapeutic approaches for Friedreich’s Ataxia
- Therapeutic use of interferon gamma in Friedreich ataxia
- Metabolic treatments of cerebellar ataxia
- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome
- Part V: Sporadic Ataxias
- Therapeutic strategies inimmune-mediated cerebellar ataxias
- Coenzyme Q10 in MSA
- State of the Art and History of Therapeutics in Ataxias