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Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches

This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite pop...

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Bibliographic Details
Main Author: Danti, Serena
Other Authors: Negrini, Nicola Contessi, Franchi, Alessandro
Format: eBook
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
Subjects:
Radiotherapy
Extracellular Matrix (ecm)
Model
Hypoxia
3d Printing
Ovarian
Tumor Microenvironment
Orthopedics
Oncology / Bicssc
Organoids
Durotaxis
3d Culture
Sk-ov-3
Self-renewal
In Vitro Model
Personalised
Epithelial Ovarian Cancer
Tissue Engineering
3d Bioprinting
3d Microfiber
Self-assembling Peptides
Cancer Cells
Personalized Therapy
Tumor Escape Mechanisms
Trafficking
Cancer
Hydrogels
Polymeric Scaffolds
Colon Cancer
Bone Matrix
Chemotherapy
Bone
Cell Lineage
Clonal Evolution
Topotaxis
Medicine And Nursing / Bicssc
Epithelial-mesenchymal Transition (emt)
Patient-derived
Polyhydroxyalkanoates (phas)
3d
Scaffold
Tumour Heterogeneity
Degradation
3rs
Tumour Modelling
Immunotherapies
Screening
Polyurethane Scaffolds
N/a
Brain Cancer
Pancreatic Cancer
Cisplatin
Fused Deposition Modeling
Pten
Radiation
Rho
Drug Resistance
3d Modeling
Colorectal Neoplasms
Longitudinal Imaging
Tumour Microenvironment (tme)
Spheroids
Rock
Cell Culture Techniques
Experimental Models
3d In Vitro Model
Treatment Resistance
Panc-1
Primary Cancer Cells
Three-dimensional
Breast Cancer
Pdac
Bone Model
Neoplasm Recurrence
Bioprinting
Mesenchymal Stromal Cell
Radioprotection
A2780
Cancer Tissue Engineering
Amoeboid Cell Migration
Hif-1a
Metastasis
Extracellular Matrix
3d Tumor Model
Egfr
3d Cancer Models
Bone Cancer
Biomaterials
Scaffolds
Calcium Phosphates
Mechanical Properties
Pancreatic Ductal Adenocarcinoma
3d Cell Culture
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
Description
Summary:This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite popular within the bioengineering community; thus, many technologies are being tested to obtain the best scaffold for each tumor. In any case, only a tight interaction of bioengineers with cancer biologists and oncologists can make such 3D models progress, with them finally reaching a clinical relevance. On the other hand, the medical community is approaching simpler 3D in vitro models not provided with sufficient extracellular matrix biomimicry, such as spheroids and organoids, which may not be self-exhaustive; therefore, cancer researchers could benefit from closer contact with bioengineers. The aim of this reprint is to help generate shared knowledge and promote strong interdisciplinary collaboration with the ultimate goal of contributing to the acceleration of the discovery and validation of more precise therapies to fight cancer.
Item Description:Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/
Physical Description:1 electronic resource (312 p.)
ISBN:books978-3-0365-6843-0
9783036568430
9783036568423

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