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Cholesterol and PI(4,5)P2 in Vital Biological Functions From Coexistence to Crosstalk

The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer protei...

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Bibliographic Details
Other Authors: Dantsker, Avia Rosenhouse- (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2023, 2023
Edition:1st ed. 2023
Series:Advances in Experimental Medicine and Biology
Subjects:
Proteins
Lipidology
Physical Biochemistry
Biophysical Chemistry
Biochemistry
Lipids
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Chapter 16. The insertion of the N-terminal domain of Gasdermin-D is increased byPI(4,5)P2 and decreased by cholesterol
  • Chapter 17. Cholesterol promotes the cooperative interaction of formins with PI(4,5)P2 to initiate actin nucleation
  • Chapter 18. Cooperation between cholesterol and PI(4,5)P2 in the regulation of Engrailed-2 homeoprotein intercellular trafficking
  • Chapter 19. Cholesterol and PI(4,5)P2 as a membrane nanoplatform for HIV assembly
  • Chapter 20. Role of Cholesterol and PI(4,5)P2 in the localization of the HIV-1 structural polyprotein Gag to the plasma membrane
  • Preface
  • 1. Mutual influence of cholesterol and PI(4,5)P2 on their levels
  • Chapter 1. Mechanism of the regulation of plasma cholesterol levels by PI(4,5)P2
  • Chapter 2. Effect of cholesterol depletion on ciliary PI(4,5)P2 levels
  • Chapter 3. Impact of cholesterol on PI(4,5)P2 levels in the brain
  • Chapter 4. Alterations in PIP2 levels in the intracellular cholesterol trafficking disorder NPC1
  • Chapter 5. Targeting cholesterol release and PI(4,5)P2 redistribution by the oral drug Miltefosine
  • 2. Cross-talk between cholesterol and PI(4,5)P2 as a factor affecting protein function
  • A. Plasma membrane ion channels
  • Chapter 6. From cross-talk to synergism: the combined effect of cholesterol and PI(4,5)P2 on inwardly rectifying potassium channels
  • Chapter 7. Link between lysosomal cholesterol and PI(4,5)P2 in the regulation of the voltage gated KCNQ2/3 potassium channel
  • Chapter 8. Cholesterol and PI(4,5)P2 binding to a ciliary membrane transient receptor potential channel
  • Chapter 9. Regulation of ell by cholesterol and PI(4,5)P2
  • Chapter 10. Cholesterol stimulates the epithelial sodium channel in a PI(4,5)P2-dependent manner
  • Chapter 11. Roles of cholesterol and PI(4,5)P2 in store operated calcium entry
  • Chapter 12. Roles of cholesterol and PI(4,5)P2 levels in the modulation of the calcium activated chloride channel TMEM16A
  • B. Lipid transport proteins
  • Chapter 13. PI(4,5)P2 facilitates ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction
  • Chapter 14. Role of PI(4,5)P2 binding in ORP2-mediated cholesterol distribution
  • Chapter 15. PI(4,5)P2-dependent transport of cholesterol from lysosomes to peroxisomes at lysosomeperoxisome contact sites
  • 3. Cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement

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