| Summary: | RESEARCH QUESTION: The objective of this investigation is to assess the benefit of treatment with single-session stereotactic radiosurgery (SRS) using linear accelerators or cobalt-60 gamma sources in comparison with microsurgical resection in patients with vestibular schwannoma requiring intervention (primary, recurrence, or residual tissue) with regard to patient-relevant outcomes. CONCLUSION: Results on patient-relevant outcomes which were usable for the report were found in a total of 3 non-randomized prospective comparative studies with a follow-up duration of about 2 years. For each of the outcomes of facial paresis and hearing ability, there is a hint of greater benefit of SRS in comparison with microsurgical resection. No data were available for the outcome of serious adverse events. With regard to the remaining outcomes, there is no hint of any greater benefit or harm of SRS in comparison with microsurgical resection. These outcomes include mortality, dizziness, headache, tinnitus, balance impairment, unfitness to work, adverse events as in complications of therapy and reinterventions as well as health-related quality of life. Based on the benefit-harm assessment across outcomes, this results in a hint of greater benefit of SRS in comparison with microsurgical resection in patients with vestibular schwannoma requiring intervention
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