| Summary: | This publication is the third in a series of American Diabetes Association compendia on the diabetic foot. Previous installments focused on the diagnosis and management of diabetes foot complications and infections. Here, the authors turn their attention to the latest evidence-based therapies for diabetic foot ulcers (DFUs). The monograph begins with an overview of the current state of diabetic foot care, as well as a brief history of oxygen therapy for the treatment of DFUs. The most recently published evidence-based data concern topical oxygen therapies, and these are described in detail. Subsequent sections summarize the evidence published mainly in the past decade for specific treatments, including autologous leucocyte, platelet, and fibrin multilayered patches; sucrose octasulfate dressings; and negative pressure wound therapy. The authors discuss the evidence related to the use of new therapies specifically for the treatment of neuropathic and neuroischemic lesions. They then look to the future at new treatment approaches in the development pipeline, as well as the emerging role of wearable technologies such as digitally connected insoles and socks in preventing DFU recurrence. Throughout the compendium, the authors present their view of current and forthcoming treatment options and identify areas worthy of additional research in the years ahead
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