NTP report on the toxicology and carcinogenicity studies of 3'-Azido-3'-Deoxythymidine (CAS NO. 30516-87-1) in genetically modified c3B6.129F1-Trp53tm1Brd N12 haploinsufficient mice (In utero and postnatal gavage study)
BACKGROUND: 3'Azido-3'-deoxythymidine (AZT) is the most widely used chemotherapeutic agent for the treatment of people with acquired immune deficiency syndrome (AIDS) or positive for human immunodeficiency virus (HIV). AZT treatment is also given to prevent transmission of HIV from pregnan...
| Corporate Author: | |
|---|---|
| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
Research Triangle Park, NC
National Toxicology Program
October 2013, 2013
|
| Series: | NTP GMM
|
| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | BACKGROUND: 3'Azido-3'-deoxythymidine (AZT) is the most widely used chemotherapeutic agent for the treatment of people with acquired immune deficiency syndrome (AIDS) or positive for human immunodeficiency virus (HIV). AZT treatment is also given to prevent transmission of HIV from pregnant mothers to children before or during birth. We tested the effects of AZT on the offspring of female mice (genetically modified to be sensitive to cancer induction) where the mothers were given the drug during pregnancy and the pups were given the drug following birth. METHOD: We exposed groups of haploinsufficient C3B6.129F1-Trp53tm1Brd N12 mice by depositing solutions of AZT in a methylcellulose solvent directly into the animals' stomachs through a tube five times per week for 30 or 45 weeks following birth; in addition, their mothers were exposed to the drug for seven days during pregnancy. Other sets of mothers and pups received only the methylcellulose solvent and served as the control groups. Tissues from 34 organs were examined for every animal. RESULTS: Exposure to AZT caused increases in the rates of liver cancer in the male pups after 45 weeks. In addition, there were occurrences of a few malignant lymphomas in both male and female pups exposed to AZT in the 30-week studies. CONCLUSIONS: We conclude that AZT caused liver cancers in male pups exposed to AZT before and following birth. Malignant lymphomas in male and female pups may have been related to AZT exposure before and following birth |
|---|---|
| Physical Description: | 1 PDF file (200 pages) illustrations |