Molecular imaging in Parkinson's disease
The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychologica...
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| Format: | eBook |
| Language: | English |
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Firenze
Firenze University Press
2011
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| Series: | Premio Tesi di Dottorato
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| Online Access: | |
| Collection: | OAPEN - Collection details see MPG.ReNa |
| Summary: | The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus. |
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| Item Description: | Creative Commons (cc), https://creativecommons.org/licenses/by-nd/3.0/ |
| Physical Description: | 68 p. |
| ISBN: | 978-88-6655-041-9 9788892736450 9788866550372 9788866550419 |