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Regional Intestinal Drug Absorption Biopharmaceutics and Drug Formulation

The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e...

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Bibliographic Details
Main Author: Gonzalez-Alvarez, Maria Isabel
Other Authors: Dahan, Arik
Format: eBook
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
Intestinal Permeability
Biomimetic Membrane
Drug-drug Interactions
Franz Cell
Physiologically-based Pharmacokinetic (pbpk) Modeling
Oral Drug Delivery
Biopharmaceutics Classification System
Gastroplus
Pbbm
Dissolution Test
Segregated Flow Intestinal Model (sfm)
Furosemide
Gastrointestinal
Nutrient Absorption
Pbpk
Human Colon Carcinoma Cell Layer (caco-2)
Ddi
Bioequivalence
Route-dependent Intestinal Metabolism
Pharmacokinetics
In Situ Perfusion
Microdevices
Drug Absorption
Traditional Model (tm)
Mucoadhesion
Zero-order Absorption
Pharmaceutical Development
First-pass Effect
Bcs Drugs
In Silico Modeling
Nutrient Digestion
Clinical Studies
Ich
Gastrointestinal Hormone
Type 2 Diabetes
Biopharmaceutics
Intestinal Perfusion
Medicine And Nursing / Bicssc
First-order Absorption
Disintegration
Quality Control
Energy Intake
Segmental-dependent Intestinal Permeability
Oral Absorption
Combined Zero- And First-order Absorption
Bcs Class Iv Drugs
Colon Absorption
Drug Solubility
Oral Peptide Delivery
Hierarchical Support Vector Regression (hsvr)
Enteric-coated
Shape
Absorption-modifying Excipients
Postprandial Glycaemia
Permeation Enhancers
Region Of The Gut
Drug Solubility/dissolution
Dissolution
Franz-pampa
Passive Drug Transport
Controlled Release Drug Product
Manometry
Phoenix Winnonlin
In Vitro
Regional/segmental-dependent Permeability And Absorption
Transit Compartment Absorption Model
Obesity
Drug Permeability
Manufacturing Industries / Bicssc
Mechanistic Modeling
Pravastatin
Ivive
Location-dependent Absorption
Regional Intestinal Permeability
Ibuprofen
In Vitro In Vivo Extrapolations
Intestinal Absorption
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
Description
Summary:The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In the book "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation" we aim to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.
Item Description:Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/
Physical Description:1 electronic resource (238 p.)
ISBN:9783036536576
9783036536583
books978-3-0365-3657-6

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