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220201 ||| eng |
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|a 9783030898731
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| 100 |
1 |
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|a Kinghorn, A. Douglas
|e [editor]
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| 245 |
0 |
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|a Antimalarial Natural Products
|h Elektronische Ressource
|c edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch
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| 250 |
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|a 1st ed. 2022
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| 260 |
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|a Cham
|b Springer International Publishing
|c 2022, 2022
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| 300 |
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|a IX, 106 p. 112 illus., 8 illus. in color
|b online resource
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| 653 |
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|a Pharmaceutical chemistry
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| 653 |
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|a Medicinal chemistry
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| 653 |
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|a Natural products
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| 653 |
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|a Chemistry, Organic
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| 653 |
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|a Parasitology
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| 653 |
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|a Pharmaceutics
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| 653 |
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|a Medicinal Chemistry
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| 653 |
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|a Natural Products
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| 653 |
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|a Organic Chemistry
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| 700 |
1 |
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|a Falk, Heinz
|e [editor]
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| 700 |
1 |
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|a Gibbons, Simon
|e [editor]
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| 700 |
1 |
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|a Asakawa, Yoshinori
|e [editor]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 490 |
0 |
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|a Progress in the Chemistry of Organic Natural Products
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| 028 |
5 |
0 |
|a 10.1007/978-3-030-89873-1
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-030-89873-1?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 547
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| 520 |
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|a This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents
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