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210907 r ||| eng |
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|a LeBlanc, Erin
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|a Hormone replacement therapy and cognition
|h Elektronische Ressource
|c Erin Leblanc, Benjamin Chan, and Heidi D Nelson ; Oregon Health Sciences University Evidence-based Practice Center
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|a Rockville, MD
|b Agency for Healthcare Research and Quality (US)
|c 2002, 2002
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|a 1 online resource
|b illustrations
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|a Includes bibliographical references
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|a Chan, Benjamin
|e [author]
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|a Nelson, Heidi D.
|e [author]
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|a Oregon Health Sciences University
|b Evidence-based Practice Center
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|a United States
|b Agency for Healthcare Research and Quality
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|a eng
|2 ISO 639-2
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|b NCBI
|a National Center for Biotechnology Information
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|a Systematic evidence reviews
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|a Title form home page. - "August 2002.". - Succeeded by Menopausal hormone therapy for the primary prevention of chronic conditions. 2012
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|u https://www.ncbi.nlm.nih.gov/books/NBK42704
|3 Volltext
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|a 610
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|a Studies did not contain enough information to assess adequately the effects of progestin use, various estrogen preparations or doses, or duration of therapy. CONCLUSIONS: In women with menopausal symptoms, HRT may have specific cognitive effects, and future studies should target these effects. The meta-analysis found a decreased risk of dementia in HRT users but most studies had important methodological limitations
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|a Two reviewers rated study quality independently and 100% agreement was reached on Jadad scores and 80% agreement was reached on U.S. Preventive Services Task Force quality scores. A final score was reached through consensus if reviewers disagreed. DATA SYNTHESIS: Studies of cognition were not combined quantitatively because of heterogeneous study design. Women symptomatic from menopause had improvements in verbal memory, vigilance, reasoning, and motor speed, but no enhancement of other cognitive functions. Generally, no benefits were observed in asymptomatic women. A Bayesian meta-analysis of 12 observational studies suggested that HRT was associated with a decreased risk of dementia (summary odds ratio, 0.66; 95% confidence interval, 0.53-0.82). However, possible biases and lack of control for potential confounders limit interpretation of these studies. Eight studies received a poor quality rating, 3 fair, and 1 good.
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|a CONTEXT: Although postmenopausal hormone replacement (HRT) therapy is widely used, its risks and benefits are not well understood. Some observational data suggest that HRT may reduce the risk of cognitive decline and dementia but results have been conflicting. OBJECTIVE: To review and evaluate studies of HRT for preventing cognitive decline and dementia in healthy postmenopausal women. DATA SOURCES: Studies with English-language abstracts identified in MEDLINE (1966-December 2000), HealthSTAR (1975-December 2000), PsychINFO (1984-December 2000); Cochrane Library databases; and articles listed in reference lists of key articles. STUDY SELECTION: Randomized controlled trials and cohort studies were reviewed for the effects of HRT on cognitive decline; cohort and case-control studies were reviewed for dementia risk. No randomized controlled trials regarding dementia risk were identified. DATA EXTRACTION: Twenty-nine studies met inclusion criteria and were rated.
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