| Summary: | The challenging management and rising costs associated with chronic wounds and related complications in many health care settings requires that interventions for chronic wound healing be supported by clinical efficacy and cost-effectiveness evidence to improve outcomes. A key modulator in the healing of normal wounds is oxygen, which is a requirement for the physiological wound healing processes of collagen deposition, epithelialization, fibroplasia, angiogenesis, and resistance to infection. Delivery of oxygen through systemic circulation is often impeded in a chronic wound environment which limits the physiological wound healing processes. Topical wound oxygen (TWO2) therapy is aimed at increasing local oxygen concentrations to support wound healing processes without depending on systemic circulation for oxygen delivery. TWO2 can be categorized into two related interventions, continuously diffused oxygen (CDO) therapy (also known as topical continuous oxygen therapy (TCOT)), and topical pressurized oxygen therapy (TPOT). The purpose of this report is to retrieve and review the existing evidence on the clinical effectiveness and cost-effectiveness of the use of CDO therapy in comparison to standard wound care alone for patients with chronic wounds. In addition, this report aims to retrieve and review the evidence-based guidelines on the use of CDO for patients with chronic wounds
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