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210907 r ||| eng |
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1 |
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|a Chao, Yi-Sheng
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|a Medicinal and synthetic cannabinoids for pediatric patients
|h Elektronische Ressource
|b a review of clinical effectiveness and guidelines
|c Yi-Sheng Chao, Suzanne McCormack
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| 250 |
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|a Version: 1.0
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| 260 |
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|a Ottawa (ON)
|b Canadian Agency for Drugs and Technologies in Health
|c October 11, 2019, 2019
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| 300 |
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|a 1 PDF file (18 pages)
|b illustrations
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|a Includes bibliographical references
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1 |
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|a McCormack, Suzanne
|e [author]
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| 710 |
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|a Canadian Agency for Drugs and Technologies in Health
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|a eng
|2 ISO 639-2
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| 989 |
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|b NCBI
|a National Center for Biotechnology Information
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|a CADTH rapid response report: summary with critical appraisal
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| 856 |
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|u https://www.ncbi.nlm.nih.gov/books/NBK551866
|3 Volltext
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|a 610
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|a Cannabinoids are pharmacologically active agents extracted from the cannabis plant. Cannabidiol and tetrahydrocannabinol (THC) are the most studied cannabinoids and both interact with endocannabinoid receptors in various human tissues. The endocannabinoid system moderates physiological functions, such as neurodevelopment, cognition, and motor control. The products naturally derived from cannabis include marijuana (dried leaves and flowers, mostly for smoking) and oral cannabinoid extracts with varying concentrations of cannabinoids, including cannabidiol and THC. THC is the main psychoactive constituent and cannabidiol seems to have no psychoactive properties. In addition, there are two synthetical cannabinoids approved by the Food and Drug Administration (FDA) in the United States, dronabinol and nabilone, which are molecules similar to a type of THC (delta-9-THC). Nabilone is also approved in Canada. Dronabinol isindicated for chemotherapy-induced nausea and vomiting in children. The use of nabilone in children is not recommended
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