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210907 r ||| eng |
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|a Rao, Ghanta N.
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|a NIEHS technical report on the subchronic toxicity study of 3'-azido-3'-deoxythymidine (AZT) and pyrazinamide combinations (CAS nos. 30516-87-1 and 98-96-4) administered by gavage to B6C3F1 mice
|h Elektronische Ressource
|c Ghanta N. Rao [and 16 others]
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| 246 |
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|a AZT and pyrazinamide
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|a [Bethesda, Md.]
|b United States Department of Health and Human Services, Public Health Service, National Institutes of Health
|c 1999, October 1999
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|a 1 PDF file (various pagings)
|b illustrations
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|a Includes bibliographical references
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|a National Institutes of Health (U.S.)
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|a National Institute of Environmental Health Sciences
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|a eng
|2 ISO 639-2
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|b NCBI
|a National Center for Biotechnology Information
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|a NIH publication
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|u https://www.ncbi.nlm.nih.gov/books/NBK557220
|3 Volltext
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|a 610
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|a The toxicity of combinations of AZT (200 or 400 mg) and pyrazinamide (1,000 or 1,500 mg) was evaluated in B6C3F1 mice treated by gavage for up to 94 days. The primary toxic effect of AZT was bone marrow suppression manifested by macrocytic anemia, thrombocytosis, and reticulocytopenia followed by reticulocytosis. Cellular depletion of bone marrow was observed microscopically. Administration of pyrazinamide alone caused mild hepatotoxicity, as evidenced by increased liver weights and by glycogen depletion of hepatocytes in a zonal pattern. AZT and pyrazinamide administered together resulted in a significant exacerbation of the hematopoietic toxicity induced by AZT alone. The hepatotoxicity of pyrazinamide was slightly augmented by AZT.
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