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210907 r ||| eng |
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|a Patnode, Carrie D.
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|a Screening for cognitive impairment in older adults: an evidence update for the U.S. Preventive Services Task Force
|h Elektronische Ressource
|c prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Kaiser Permanente Research Affiliates Evidence-based Practice Center, Kaiser Permanente Center for Health Research ; investigators, Carrie D. Patnode, Leslie A. Perdue, Rebecca C. Rossom, Megan C. Rushkin, Nadia Redmond, Rachel G. Thomas, Jennifer S. Lin
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|a Rockville, MD
|b Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services
|c 2020, February 2020
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|a 1 PDF file (viii, 473 pages)
|b illustrations
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|a U.S. Preventive Services Task Force
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|a United States
|b Agency for Healthcare Research and Quality
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|a Oregon Evidence-based Practice Center (Center for Health Research (Kaiser-Permanente Medical Care Program. Northwest Region))
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|a eng
|2 ISO 639-2
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|b NCBI
|a National Center for Biotechnology Information
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|a Evidence synthesis
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|u https://www.ncbi.nlm.nih.gov/books/NBK554654
|3 Volltext
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|a 610
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|a The test performance of the few instruments evaluated to detect MCI was lower than the sensitivity and specificity to detect dementia and there is little evidence for any pharmacologic or nonpharmacologic interventions to preserve or improve patient functioning in persons with MCI.
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|a OBJECTIVE: We conducted this systematic review to support the U.S. Preventive Services Task Force in updating its 2014 recommendation on screening for cognitive impairment in older adults. Our review addressed the direct evidence on the benefits and harms of screening for cognitive impairment versus no screening, the test accuracy of screening instruments to detect mild cognitive impairment (MCI) and dementia, and the benefits and harms of treatment for MCI and mild to moderate dementia among community-dwelling older adults age 65 years and older. CONCLUSIONS: Several brief screening instruments can adequately detect cognitive impairment, especially in populations with a higher prevalence of underlying dementia. There is no empiric evidence, however, that screening for cognitive impairment or early diagnosis of cognitive impairment improves patient, caregiver, family, or clinician decision making or other important outcomes nor causes harm.
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|a In general, there is support that AChEIs and memantine and interventions that support caregivers, including those that help coordinate care for patients and caregivers, can result in small improvements in the short term. Unfortunately, the average effects of these benefits are quite small and likely not of clinical significance. Any benefits are further limited by the commonly experienced side effects of medications and the limited availability of complex caregiver interventions. Cognitive stimulation and training, exercise interventions, and other medications and supplements showed some favorable effects on patients' cognitive and physical function, but trial evidence lacked consistency and the estimates of benefit were imprecise. There is less evidence related to screening for and treating MCI.
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