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210512 ||| eng |
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|a 9783039438143
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|a 9783039438136
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|a books978-3-03943-814-3
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|a Kuligowski, Julia
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| 245 |
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|a Sample Preparation in Metabolomics
|h Elektronische Ressource
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| 260 |
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|a Basel, Switzerland
|b MDPI - Multidisciplinary Digital Publishing Institute
|c 2021
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| 300 |
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|a 1 electronic resource (208 p.)
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| 653 |
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|a metabolite extraction
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| 653 |
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|a sampling
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| 653 |
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|a hydrophilic interaction liquid chromatography
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| 653 |
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|a high resolution mass spectrometry
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| 653 |
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|a liquid chromatography-mass spectrometry
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| 653 |
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|a NMR
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| 653 |
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|a metadata standardization
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| 653 |
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|a trees
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| 653 |
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|a multicellular tumor spheroids
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| 653 |
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|a electromembrane extraction
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| 653 |
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|a forestry
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| 653 |
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|a multi-segment injection
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| 653 |
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|a microvesicles
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| 653 |
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|a MiaPaCa-2
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| 653 |
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|a exosomes
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| 653 |
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|a human cell line
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| 653 |
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|a diagnostics
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| 653 |
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|a nuclear magnetic resonance (NMR)
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| 653 |
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|a design of experiments
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| 653 |
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|a AMOPLS
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| 653 |
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|a method development
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| 653 |
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|a nuclear magnetic resonance spectroscopy
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| 653 |
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|a mass spectrometry
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| 653 |
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|a human milk
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| 653 |
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|a GC-MS
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| 653 |
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|a oxaliplatin
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| 653 |
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|a extraction
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| 653 |
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|a ion mobility spectrometry
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| 653 |
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|a plant natural products
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| 653 |
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|a microscopic samples
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| 653 |
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|a gas chromatography
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| 653 |
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|a plant metabolomics
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| 653 |
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|a cell line
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| 653 |
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|a gas chromatography-mass spectrometry (GC-MS)
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| 653 |
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|a IT-139
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| 653 |
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|a high-resolution magic angle spinning
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| 653 |
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|a harvesting
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| 653 |
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|a normalization
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| 653 |
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|a AsPC-1
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| 653 |
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|a databases
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| 653 |
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|a biomarkers
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| 653 |
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|a lipidomics
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| 653 |
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|a capillary electrophoresis-mass spectrometry
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| 653 |
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|a metabolome
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| 653 |
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|a metabolites
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| 653 |
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|a human plasma
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| 653 |
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|a Panc-1
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| 653 |
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|a cardiovascular disease
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| 653 |
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|a extracellular vesicles
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| 653 |
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|a capillary electrophoresis-mass spectrometry (CE-MS)
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| 653 |
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|a metabolic pathways
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| 653 |
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|a drug discovery
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| 653 |
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|a liquid chromatography
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| 653 |
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|a 20% FCS
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| 653 |
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|a metabolic profiling
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| 653 |
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|a metallodrugs
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| 653 |
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|a liquid chromatography-mass spectrometry (LC-MS)
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| 653 |
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|a KP1339
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| 653 |
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|a metabonomics
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| 653 |
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|a LC-MS
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| 653 |
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|a Medicine and Nursing / bicssc
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| 653 |
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|a sample preparation
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| 653 |
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|a LC-MS/MS
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| 653 |
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|a metabolomics
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| 700 |
1 |
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|a Quintás, Guillermo
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| 700 |
1 |
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|a Kuligowski, Julia
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| 700 |
1 |
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|a Quintás, Guillermo
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b DOAB
|a Directory of Open Access Books
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| 500 |
|
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|a Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/
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| 028 |
5 |
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|a 10.3390/books978-3-03943-814-3
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| 856 |
4 |
2 |
|u https://directory.doabooks.org/handle/20.500.12854/68554
|z DOAB: description of the publication
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| 856 |
4 |
0 |
|u https://www.mdpi.com/books/pdfview/book/3575
|7 0
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 610
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| 082 |
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|a 333
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|a 580
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|a 140
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|a Metabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field of sample preparation for metabolomics studies. Novel technologies presented include electromembrane extraction of polar metabolites from plasma samples and guidelines for the preparation of biospecimens for the analysis with high-resolution μ magic-angle spinning nuclear magnetic resonance (HR-μMAS NMR). In the following chapters, the spotlight is on sample preparation approaches that have been optimized for diverse bioanalytical applications, including the analysis of cell lines, bacteria, single spheroids, extracellular vesicles, human milk, plant natural products and forest trees.
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