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210512 ||| eng |
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|a 9783039213283
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|a 9783039213276
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|a books978-3-03921-328-3
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|a Haas, Richard H.
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|a Mitochondrial Dysfunction in Aging and Diseases of Aging
|h Elektronische Ressource
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|b MDPI - Multidisciplinary Digital Publishing Institute
|c 2019
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|a 1 electronic resource (270 p.)
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|a metabokines
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|a aging
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|a mitochondrial dysfunction
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|a retina
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|a immunosenescence
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|a optic nerve
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|a age-related diseases
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|a ultraviolet
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|a proteostasis
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|a inflammation
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|a coenzyme Q10
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|a insulin resistance
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|a n/a
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|a exosomes
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|a cytokines
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|a glaucoma
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|a mitochondria
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|a multiple sclerosis
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|a cardiomyopathy
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|a heart failure
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|a ageing
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|a ROS
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|a senescence
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|a axonal transport
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|a aerobic
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|a neurodegeneration
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|a genetic mutations
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|a ALS
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|a Parkin
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|a crabtree effect
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|a SOD1
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|a neuroinflammation
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|a drug-induced mitochondrial toxicity
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|a PINK1
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|a diabetic retinopathy
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|a reactive oxygen species
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|a sphingolipids
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|a 25(OH)D
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|a 1
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|a Biology, life sciences / bicssc
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|a mitochondrial
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|a purinergic signaling
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|a age-related macular degeneration
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|a cancer
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|a de-emergence
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|a cardiovascular disease
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|a eIF2?
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|a stress response
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|a nucleotide metabolism
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|a integrated cell stress response
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|a cell danger response
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|a Miro1
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|a exercise
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|a 25(OH)2D
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|a neurodegenerative disease
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|a autophagy
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|a morbidity and mortality
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|a mitochondrial transfer
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|a adaptive immunity
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|a skin
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|a healing cycle
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|a DNA damage
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|a Alzheimer's disease
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|a prevention
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|a NAD+
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|a Parkinson's disease
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|a metabolism
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|a photoageing
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|a polypharmacy
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|a type 2 diabetes
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|a mitophagy
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|a lysosome
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|a pasteur effect
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|a innate immunity
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|a eng
|2 ISO 639-2
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|b DOAB
|a Directory of Open Access Books
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|a Creative Commons (cc), https://creativecommons.org/licenses/by-nc-nd/4.0/
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|a 10.3390/books978-3-03921-328-3
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4 |
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|u https://directory.doabooks.org/handle/20.500.12854/53609
|z DOAB: description of the publication
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|u https://www.mdpi.com/books/pdfview/book/1606
|7 0
|x Verlag
|3 Volltext
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|a 610
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|a 380
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|a 700
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|a This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
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